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Histochemical Staining of Arabidopsis thaliana Secondary Cell Wall Elements

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Published on: May 13, 2014

Two new compounds from Xanthium strumarium.

Rong-Hua Yin^1,2, Xue Bai¹, Tao Feng³

¹a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming 650201 , China.

Journal of Asian Natural Products Research

|December 3, 2015

Summary

Researchers isolated new compounds from Xanthium strumarium seeds. These compounds, including fructusol A and 2-hydroxy-xanthiazone, showed no significant antifungal activity against Candida albicans in vitro.

Keywords:

2-hydroxy-xanthiazone Xanthium strumarium antifungal activities fructusol A

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Area of Science:

Natural Product Chemistry
Pharmacognosy
Mycology

Background:

Xanthium strumarium seeds are a source of bioactive natural products.
Lignans and thiazine derivatives are classes of compounds with diverse biological activities.
Investigating novel compounds for potential therapeutic applications is ongoing.

Purpose of the Study:

To isolate and characterize new chemical constituents from Xanthium strumarium seeds.
To evaluate the in vitro antifungal activity of isolated compounds against Candida albicans.

Main Methods:

Isolation of compounds using chromatographic techniques.
Structure elucidation of new compounds via extensive spectroscopic analysis (NMR, MS).
Antifungal activity testing using broth microdilution method.

Main Results:

One new lignan, fructusol A (1), and one new thiazine derivative, 2-hydroxy-xanthiazone (2), were identified.
Eight known compounds were also isolated from the plant extract.
Compounds 1-3 exhibited no significant antifungal activity against Candida albicans, with minimum inhibitory concentrations (MIC90) greater than 128 μg/ml.

Conclusions:

The new compounds fructusol A and 2-hydroxy-xanthiazone were structurally characterized.
The tested compounds from Xanthium strumarium seeds do not possess potent in vitro antifungal activity against Candida albicans.