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Related Concept Videos

Genomics02:02

Genomics

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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Evolutionary Relationships through Genome Comparisons02:54

Evolutionary Relationships through Genome Comparisons

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Genome comparison is one of the excellent ways to interpret the evolutionary relationships between organisms. The basic principle of genome comparison is that if two species share a common feature, it is likely encoded by the DNA sequence conserved between both species. The advent of genome sequencing technologies in the late 20th century enabled scientists to understand the concept of conservation of domains between species and helped them to deduce evolutionary relationships across diverse...
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Human Genetics01:28

Human Genetics

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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
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Genome Annotation and Assembly03:36

Genome Annotation and Assembly

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The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.
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Next-generation Sequencing03:00

Next-generation Sequencing

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The first human genome sequencing project cost $2.7 billion and was declared complete in 2003, after 15 years of international cooperation and collaboration between several research teams and funding agencies. Today, with the advent of next-generation sequencing technologies, the cost and time of sequencing a human genome have dropped over 100 fold.
Next-Generation Sequencing Methods
Although all next-generation methods use different technologies, they all share a set of standard features....
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The Central Dogma01:20

The Central Dogma

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The central dogma explains the flow of genetic information from DNA nucleotides to the amino acid sequence of proteins.
RNA is the Missing Link Between DNA and Proteins
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Related Experiment Video

Updated: Mar 29, 2026

Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C
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Deciphering High-Resolution 3D Chromatin Organization via Capture Hi-C

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Deciphering the human antigenome.

Alessandro Sette1, Theodore R Schenkelberg2, Wayne C Koff3

  • 1a La Jolla Institute for Allergy and Immunology , La Jolla , CA , USA.

Expert Review of Vaccines
|December 3, 2015
PubMed
Summary
This summary is machine-generated.

Technological advances in genomics and bioinformatics can identify new targets for vaccines and immunotherapies. Scientists met to discuss using these tools to understand the human antigenome for disease control.

Keywords:
Human vaccines projectT cellsantibodiesantigenomebioinformaticsepitopes

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Area of Science:

  • Immunology
  • Bioinformatics
  • Genomics

Background:

  • Recent technological advancements in genomics, mass spectrometry, and epitope identification algorithms.
  • These technologies present opportunities for identifying novel antigenic targets.

Purpose of the Study:

  • To discuss the utilization of advanced technologies for deciphering the human antigenome.
  • To explore the application of antigenome information for the prevention and control of infectious and neoplastic diseases.

Main Methods:

  • A meeting of leading immunologists and bioinformatics scientists.
  • Discussion on leveraging genomics, mass spectrometry, and epitope identification algorithms.

Main Results:

  • Identified potential for novel antigenic targets.
  • Explored strategies for antigenome deciphering and application.

Conclusions:

  • Advanced technologies hold promise for vaccine and immunotherapeutic development.
  • Deciphering the human antigenome is crucial for controlling infectious and neoplastic diseases.