Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

6.3K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
When the tumor suppressor genes develop mutations or are lost, cells start growing out of control, leading to cancer. However, a single functional copy of the tumor suppressor gene is enough for the cells to maintain their normal functions and cell...
6.3K
Loss of Tumor Suppressor Gene Functions01:12

Loss of Tumor Suppressor Gene Functions

2.0K
2.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

10.0K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
10.0K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

3.0K
3.0K
Abnormal Proliferation02:23

Abnormal Proliferation

5.4K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.4K
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

4.9K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
4.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Dietary restriction during active cancer therapy is associated with improved treatment response: a systematic review and meta-analysis.

Cancer biology & medicine·2026
Same author

Integrating machine learning and pathway modelling to explore factors associated with chronic post-surgical pain and quality of life: a secondary observational analysis of the ENIGMA-II trial.

BJA open·2026
Same author

Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial.

PloS one·2026
Same author

Body-wide multi-omic counteraction of aging with GLP-1R agonism.

Cell metabolism·2026
Same author

Correction: FOXP4 Is a Direct YAP1 Target That Promotes Gastric Cancer Stemness and Drives Metastasis.

Cancer research·2026
Same author

Impacts of COVID-19 pandemic on early life gut microbiome.

Gut microbes·2025

Related Experiment Video

Updated: Mar 29, 2026

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60
08:13

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60

Published on: December 7, 2017

7.3K

TIP30: A Novel Tumor-Suppressor Gene.

Xin Yu1, Zheng Li, William K K Wu

  • 1Department of Dermatology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.

Oncology Research
|December 3, 2015
PubMed
Summary

The tumor suppressor TIP30 (also known as CC3) is crucial in preventing cancer. Its reduced expression correlates with tumor progression and increased cancer incidence, highlighting its role in tumor development.

More Related Videos

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

7.1K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

2.4K

Related Experiment Videos

Last Updated: Mar 29, 2026

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60
08:13

Live-imaging of Breast Epithelial Cell Migration After the Transient Depletion of TIP60

Published on: December 7, 2017

7.3K
Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres
06:52

Discovery of Driver Genes in Colorectal HT29-derived Cancer Stem-Like Tumorspheres

Published on: July 22, 2020

7.1K
Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies
07:47

Author Spotlight: Unveiling Transmembrane Protein Family-Related Markers in Gastric Cancer and Implications for Targeted Therapies

Published on: September 15, 2023

2.4K

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • TIP30 (also known as CC3) was initially identified as a candidate tumor suppressor in 1997.
  • Recent studies confirm TIP30's tumor-suppressor role, showing its expression is often reduced in various human tumors, correlating with advanced disease.
  • TIP30 deficiency is linked to increased spontaneous tumor development, including hepatocellular carcinoma in mice.

Purpose of the Study:

  • To review the current understanding of TIP30's function in cancer.
  • To consolidate knowledge on TIP30's involvement in tumor development and progression.
  • To highlight TIP30 as a significant tumor suppressor in cancer research.

Main Methods:

  • Literature review of studies on TIP30 and cancer.
  • Analysis of experimental data on TIP30 expression in human tumors.
  • Examination of findings from TIP30 knockout mouse models.

Main Results:

  • TIP30 protein levels are frequently downregulated in diverse human cancers.
  • Reduced TIP30 expression is associated with tumor progression and metastasis.
  • TIP30 plays a role in regulating apoptosis, cell growth, angiogenesis, DNA repair, and metabolism.

Conclusions:

  • TIP30 is a critical tumor suppressor gene whose downregulation contributes to cancer development and progression.
  • Further research into TIP30's mechanisms could offer new therapeutic strategies for cancer.
  • This review provides a comprehensive overview of TIP30's multifaceted role in oncogenesis.