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Association between FKBP5 Functional Polymorphisms and Completed Suicide.

Sylwia Fudalej¹, Maciej Kopera, Dorota Wołyńczyk-Gmaj

¹Department of Psychiatry, Medical University of Warsaw, Warsaw, Poland.

Neuropsychobiology

|December 3, 2015

Summary

Genetic variations in FKBP5 are linked to completed suicide risk. Specifically, the FKBP5 rs3800373 C allele may increase vulnerability, suggesting a genetic component in suicide behavior.

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Published on: November 30, 2015

Area of Science:

Neuroscience
Genetics
Psychiatry

Background:

Hypothalamic-pituitary-adrenal (HPA) axis dysfunction impairs stress response.
FKBP5 influences HPA axis activity and glucocorticoid receptor function, impacting negative feedback and resistance.
Altered stress response mechanisms are implicated in the biological basis of suicide.

Purpose of the Study:

To investigate the association between FKBP5 functional polymorphisms (rs1360780 and rs3800373) and completed suicide.
To explore the role of FKBP5 genetic variations in suicide vulnerability.

Main Methods:

Genotyping of FKBP5 polymorphisms rs1360780 and rs3800373.
Analysis of a cohort comprising 563 suicide victims and 475 controls.

Main Results:

A significant association was found between the high-induction rs3800373 C allele and completed suicide (OR = 1.36, p = 0.007).
Genotype distribution supported a codominant inheritance model for rs3800373.
The rs1360780 (T)-rs3800373 (C) haplotype, in strong linkage disequilibrium, was associated with suicide risk (OR = 1.34, p = 0.010).

Conclusions:

Genetic alterations in FKBP5 may contribute to an individual's vulnerability to suicide.
These findings highlight FKBP5 as a potential genetic factor influencing suicide behavior.