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Flexible opto-electronics enabled microfluidics systems with cloud connectivity for point-of-care micronutrient

Stephen Lee1, A J Aranyosi1, Michelle D Wong2

  • 1MC10 Inc., 10 Maguire Road, Bldg 3, Lexington, MA 02421 USA.

Biosensors & Bioelectronics
|December 3, 2015
PubMed
Summary

A new credit card-sized device uses paper microfluidics and electronics for accurate micronutrient testing in remote areas. This point-of-care system enables real-time tracking of deficiencies, overcoming infrastructure challenges.

Keywords:
DiagnosticFlexible microelectronicsMicronutrientsNear field communicationPaper microfluidic assayPoint-of-care

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Area of Science:

  • Biomedical Engineering
  • Point-of-Care Diagnostics
  • Microfluidics

Background:

  • Developing countries face challenges in deploying medical diagnostics due to limited infrastructure and healthcare professionals.
  • Existing diagnostic methods often require specialized equipment and controlled environments, hindering use in resource-limited settings.

Purpose of the Study:

  • To develop and clinically test a novel electronics-enabled microfluidic paper-based analytical device (EE-μPAD).
  • To enable quantitative measurement of micronutrient concentrations in decentralized, resource-limited settings.

Main Methods:

  • Development of a credit card-sized, ultrathin device integrating paper-based microfluidics with flexible electronics and optoelectronic sensors.
  • Incorporation of autonomous self-calibration, plasma separation, flow monitoring, timing, and data storage.
  • Wireless data transfer to a mobile application for geo-tagging and remote server transmission.

Main Results:

  • Clinical tests (n=95) demonstrated comparable sensitivity and specificity to ELISA-based tests for micronutrient levels.
  • The EE-μPAD system enables autonomous operation and simultaneous processing of multiple devices.
  • Instantaneous data acquisition and global aggregation of diagnostics data were achieved.

Conclusions:

  • The EE-μPAD system offers a viable solution for quantitative micronutrient analysis in resource-limited settings.
  • This integrated point-of-care system facilitates rapid, distributed surveillance of disease prevalence and geographical progression.
  • The technology addresses infrastructural limitations and enhances accessibility of medical diagnostics globally.