Related Experiment Video

Updated: Mar 29, 2026

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring
06:11

Author Spotlight: Exploring the Long-Term Health Impacts of Intracytoplasmic Sperm Injection on Offspring

Published on: May 17, 2024

1.3K

Transient Neonatal Diabetes Mellitus followed by recurrent asymptomatic hypoglycaemia: a case report

Archana Priyadarshi1, Charles F Verge2,3, Leah Vandervliet4

  • 1Royal Hospital for Women, Randwick, Sydney, Australia. archanapriyadarshi@yahoo.co.in.

BMC Pediatrics
|December 4, 2015
PubMed

Insights

Transient neonatal diabetes mellitus (TNDM) can recur as asymptomatic hypoglycemia weeks after remission. Close monitoring and aggressive feeding are crucial for managing TNDM infants.

Area of Science:

  • Neonatology
  • Endocrinology
  • Genetics

Background:

  • Transient neonatal diabetes mellitus (TNDM) is the most common cause of diabetes in newborns.
  • Often linked to genetic aberrations at the 6q24 gene locus, TNDM typically resolves by three months but increases future type 2 diabetes risk.
  • The disorder presents in three phases: neonatal diabetes, apparent remission, and potential relapse.

Observation:

  • A neonate with low birth weight and growth retardation presented with transient diabetes mellitus at birth.
  • Recurrent asymptomatic hypoglycemia was detected at six weeks of age, four weeks after diabetes remission, via pre-feed blood glucose monitoring.
  • No other congenital malformations were observed in the infant.

Findings:

  • Neonates in remission from TNDM can experience recurrent asymptomatic hypoglycemia.
  • This hypoglycemia can persist for weeks and may be missed without routine pre-feed blood glucose monitoring.
  • Aggressive enteral feeding with high glucose delivery rates may be necessary to maintain normoglycemia.

Implications:

  • Highlights the importance of continued vigilance and monitoring in infants with TNDM even after apparent remission.
  • Suggests a potential need for adjusted feeding strategies in infants recovering from TNDM to prevent hypoglycemia.
  • Underscores the value of pre-feed blood glucose monitoring in detecting subclinical metabolic disturbances in this population.
Abstract

More Related Videos

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test06:59

Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test

Published on: November 13, 2016

11.5K
Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

10.4K

Related Concept Videos

Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
4.4K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
1.3K
Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
5.5K
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
6.0K
Diabetes: Symptoms, Diagnosis, and Complications01:15

Diabetes: Symptoms, Diagnosis, and Complications

For most patients, experiencing several weeks of polyuria, polydipsia, fatigue, and significant weight loss may indicate the presence of diabetes. Furthermore, adults displaying the phenotypic appearance of type 2 diabetes (particularly those who are obese and not initially insulin-requiring), may have islet cell autoantibodies, suggesting autoimmune-mediated β cell destruction and a diagnosis of latent autoimmune diabetes of adults (LADA). The categorization of glucose homeostasis is...
2.8K
Glucose Transporters01:27

Glucose Transporters

Glucose transporters facilitate the transport of glucose across the cell membrane. In addition to glucose, some glucose transporters can also aid the movement of other hexoses such as fructose, mannose, and galactose.
Facilitated diffusion-glucose transporters (GLUTs) are encoded by the solute-linked carrier (SLC) family 2, subfamily A gene family, or SLC2A. The 14 GLUT protein members are distributed into three classes:
28.2K