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Updated: Mar 29, 2026

Rapid Identification of Chemical Genetic Interactions in Saccharomyces cerevisiae
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The Saccharomyces Genome Database: A Tool for Discovery.

J Michael Cherry1

  • 1Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-5120.

Cold Spring Harbor Protocols
|December 4, 2015
PubMed
Summary

The Saccharomyces Genome Database (SGD) provides comprehensive information on Saccharomyces cerevisiae biology. This essential resource aids researchers by integrating gene functions, phenotypes, and interactions for experimental design and analysis.

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Area of Science:

  • Yeast Genetics and Genomics
  • Molecular and Cellular Biology
  • Bioinformatics and Computational Biology

Background:

  • The Saccharomyces Genome Database (SGD) is the primary community repository for budding yeast, Saccharomyces cerevisiae.
  • It consolidates published experimental results on yeast chromosomal features, genes, and gene products.

Purpose of the Study:

  • To serve as a comprehensive encyclopedia of yeast cell biology.
  • To provide public access to all published experimental results on yeast.
  • To support life science students, educators, and researchers.

Main Methods:

  • Integration of diverse biological information including gene function, phenotype, interactions, regulation, complexes, and pathways.
  • Development of a unique web resource (http://yeastgenome.org) for data accessibility.

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  • Implementation of custom search and visualization tools for data exploration.

    • Main Results:

    • Creation of a unified web resource detailing Saccharomyces cerevisiae biology.
    • Archiving of experimentally defined gene functions, mutant phenotypes, and sequence homologies.
    • Facilitation of data-driven biological research and experimental planning.

    Conclusions:

    • The SGD is an indispensable tool for yeast research, enabling efficient experimental design and data analysis.
    • It serves as a foundational platform for understanding numerous fields within biological research.
    • Public accessibility to curated yeast data significantly advances scientific discovery and education.