Related Experiment Video
Updated: Mar 29, 2026
10:19
Generation of Genetically Modified Mice through the Microinjection of Oocytes
Published on: June 15, 2017
21.9K
Genetic engineering of mammals
1Division of Animal Sciences, Animal Sciences Research Center, University of Missouri, Columbia, MO, 65211, USA. wellskev@missouri.edu.
Cell and Tissue Research
|December 4, 2015
Summary
Genetic engineering is now feasible in domesticated mammals, moving beyond mouse models for livestock fertility and human condition research. Selecting appropriate species models ensures accurate physiological and anatomical relevance.
Area of Science:
- Mammalian genetics
- Reproductive biology
- Animal models
Background:
- Historically, mice were the primary model for genetic engineering in mammalian reproduction.
- Advances in genetic engineering techniques have expanded capabilities beyond mice.
Purpose of the Study:
- To highlight the expanded scope of genetic engineering in domesticated mammals.
- To advocate for the use of species-specific models in research.
Main Methods:
- Random transgene integration
- Homologous recombination
- Gene editing techniques
Main Results:
- Genetic manipulations previously limited to mice are now routine in many domesticated mammal species.
- Direct investigation of fertility in livestock is now possible without relying on mouse models.
Conclusions:
- Domesticated mammals are now viable models for studying fertility and human conditions.
- Model selection should prioritize species-specific physiology, anatomy, and size for accurate research outcomes.
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