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Updated: Mar 29, 2026
Brain Infarct Segmentation and Registration on MRI or CT for Lesion-symptom Mapping
Published on: September 25, 2019
The Infarct Shape Predicts Progressive Motor Deficits in Patients with Acute Lacunae-sized Infarctions in the
1Department of Neurology, Center Hospital of Weihai, the Teaching Hospital of Medical College, Qingdao University, China.
Objective:
This study was performed to analyze the lesion patterns of lacunae-sized infarctions on diffusion-weighted imaging (DWI) findings in the perforating arterial territory, and to determine whether this pattern of satellite lesions affected progressive motor defect (PMD).
Methods:
Seventy-five patients with acute lacunae-sized infarctions in the perforating arterial territory (pons or territory of the lenticulostriate arteries), which was confirmed by cranial magnetic resonance image (MRI), were enrolled in this study. These patients were divided into PMD (n=30) and non-progressive motor defect (NPMD) (n=45) groups according to the dynamic scores of the National Institutes of Health Stroke Scale (NIHSS) within 7 days after stroke. The lesion patterns of lacunae-sized infarctions were divided into single oval or satellite lesions signs based on DWI. The risk factors of stroke and the clinical characteristics of all the subjects, including neurological deficits, infarction lesion patterns in image, and the condition of the basilar artery, were comparatively analyzed.
Results:
The constituent ratio of satellite lesions signs [20/30 (66.7%)] in the PMD group was higher than that [10/45 (22.2%)] of the NPMD group (χ(2)= 6.1, p=0.013). Mean NIHSS scores in the PMD group on admission were higher than that of the NPMD group (4.60±1.40 vs. 3.75±1.2, t=2.81, p=0.003). A logistic regression analysis showed that the pattern of satellite lesions was associated with PMD. 〔odds ratio (OR): 3.0, 95% confidence interval (CI) 1.25-7.17, p=0.014〕.
Conclusion:
Satellite lesions are one of the features of lacunae-sized infarctions patterns, which might be an independent predictor in DWI findings for PMD in patients with lacunae-sized infarctions in the perforating arterial territory.
Insights
Satellite lesions on diffusion-weighted imaging (DWI) are linked to progressive motor deficits in patients with lacunar infarctions. This finding suggests satellite lesions may predict motor decline after stroke.
Area of Science:
- Neurology
- Radiology
- Stroke Research
Background:
- Lacunar infarctions are small strokes often affecting the perforating arterial territory.
- Diffusion-weighted imaging (DWI) is crucial for detecting acute ischemic lesions.
- Progressive motor defect (PMD) following stroke impacts patient recovery and prognosis.
Purpose of the Study:
- To analyze lesion patterns of lacunar infarctions on DWI.
- To investigate the association between satellite lesions and progressive motor defect (PMD).
- To determine if satellite lesions are independent predictors of PMD in lacunar stroke.
Main Methods:
- Seventy-five patients with lacunar infarctions in perforating arterial territories were analyzed using cranial MRI and DWI.
- Patients were categorized into PMD (n=30) and non-progressive motor defect (NPMD) (n=45) groups based on NIHSS scores within 7 days.
- Lesion patterns were classified as single oval or satellite lesions; risk factors and clinical characteristics were compared.
Main Results:
- The prevalence of satellite lesions was significantly higher in the PMD group (66.7%) compared to the NPMD group (22.2%).
- Mean NIHSS scores on admission were higher in the PMD group.
- Logistic regression revealed satellite lesions as an independent predictor of PMD (OR: 3.0, 95% CI: 1.25-7.17).
Conclusions:
- Satellite lesions represent a distinct pattern in lacunar infarctions visible on DWI.
- This lesion pattern is associated with progressive motor deficits.
- Satellite lesions may serve as an independent predictor for PMD in patients with lacunar infarctions in perforating arterial territories.
