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Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
Published on: December 3, 2017
Diagnosis and Management of Periprosthetic Elbow Infection
Jeremy S Somerson1, Mark E Morrey2, Joaquin Sanchez-Sotelo2
1Department of Orthopaedics, University of Texas Health Science Center at San Antonio, 7730 Floyd Curl Drive, San Antonio, TX 78229.
Abstract:
➤ Periprosthetic elbow infections rarely involve systemic symptoms such as fever or malaise.➤ Unlike tests for periprosthetic hip and knee infections, the diagnostic utility of blood testing and joint aspiration for periprosthetic elbow infection has not been demonstrated to date.➤ Intraoperative histological analysis has good specificity (93.1%) but very low sensitivity (51.3%) for periprosthetic elbow infection.➤ Emerging diagnostic options such as implant sonication, molecular analysis, and advanced synovial fluid cytokine and protein analysis may reduce diagnostic uncertainty in the future.➤ Recommended surgical treatment options for an infection at the site of an elbow arthroplasty include implant retention and debridement, two-stage revision with or without techniques for restoration of bone stock and triceps continuity, and resection arthroplasty.
Insights
Diagnosing periprosthetic elbow infections is challenging, as standard tests lack proven utility. Future diagnostic tools and surgical options offer hope for improved management of these rare infections.
Area of Science:
- Orthopedic Surgery
- Infectious Diseases
- Diagnostic Medicine
Background:
- Periprosthetic elbow infections are uncommon and rarely present with systemic symptoms like fever.
- The diagnostic accuracy of blood tests and joint aspiration for elbow periprosthetic joint infections (EPJIs) remains unproven, unlike for hip and knee counterparts.
- Intraoperative histological analysis demonstrates high specificity but low sensitivity for diagnosing EPJIs.
Purpose of the Study:
- To review the diagnostic challenges and current management strategies for periprosthetic elbow infections.
- To highlight the limitations of existing diagnostic methods for EPJIs.
- To explore emerging diagnostic technologies and surgical interventions for EPJIs.
Main Methods:
- Literature review of diagnostic modalities for periprosthetic elbow infections.
- Analysis of the diagnostic performance of intraoperative histological examination.
- Evaluation of current and emerging surgical treatment options for EPJIs.
Main Results:
- Systemic symptoms are rare in periprosthetic elbow infections.
- Blood tests and joint aspiration have not been validated for diagnosing EPJIs.
- Intraoperative histology shows 93.1% specificity and 51.3% sensitivity.
- Novel diagnostic approaches like implant sonication and molecular analysis show promise.
- Surgical options include debridement, two-stage revision, and resection arthroplasty.
Conclusions:
- Accurate diagnosis of periprosthetic elbow infections remains a significant clinical challenge.
- Emerging diagnostic tools are expected to improve diagnostic certainty in the future.
- A range of surgical strategies exist for managing these complex infections.
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