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Body Mass Index Modifies an Association between Self-Reported Regular Exercise and Proteinuria
Yasuyuki Nagasawa1, Ryohei Yamamoto, Maki Shinzawa
1Department of Internal Medicine, Division of Kidney and Dialysis, Hyogo College of Medicine.
Journal of Atherosclerosis and Thrombosis
|December 4, 2015
Summary
Regular exercise is linked to lower rates of proteinuria and kidney dysfunction. However, high body mass index may weaken this protective effect in men.
Area of Science:
- Nephrology
- Public Health
- Exercise Physiology
Background:
- Metabolic syndrome can lead to proteinuria and chronic kidney disease (CKD).
- The direct impact of exercise on proteinuria and kidney dysfunction is not fully understood.
- Obesity's role in modulating the exercise-kidney relationship requires investigation.
Purpose of the Study:
- To determine the association between regular exercise and the prevalence of proteinuria.
- To investigate the association between regular exercise and kidney dysfunction.
- To examine if obesity attenuates the potential protective effects of exercise on kidney health.
Main Methods:
- A cross-sectional cohort study of 292,013 participants in Japan.
- Exercise habits were quantified using an exercise score (0-3).
- Proteinuria was assessed via dipstick test; kidney dysfunction was defined as estimated glomerular filtration rate (GFR) < 45 ml/min/1.73 m(2).
Main Results:
- Higher exercise scores were significantly associated with lower odds of proteinuria in both males and females.
- In males, obesity (high BMI) attenuated the association between exercise and proteinuria.
- In females, the association between exercise and lower proteinuria prevalence was independent of BMI.
- Similar trends were observed for kidney dysfunction, with BMI attenuation noted in males.
Conclusions:
- Regular exercise is associated with a reduced prevalence of proteinuria and kidney dysfunction.
- High BMI may diminish the renoprotective effects of exercise in men.
- Exercise remains a potentially beneficial lifestyle factor for kidney health, with varying impact influenced by obesity.
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