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Drug-induced osteoporosis.

D J Mazanec, J M Grisanti

    Cleveland Clinic Journal of Medicine
    |May 1, 1989
    PubMed
    Summary

    Corticosteroids, heparin, and methotrexate can cause bone loss and osteoporosis, especially at high doses. This review covers their effects, mechanisms, and prevention strategies.

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    Radiology·1995

    Area of Science:

    • Pharmacology
    • Endocrinology
    • Bone Metabolism

    Background:

    • Corticosteroids are a common cause of drug-induced bone loss.
    • High doses of heparin and methotrexate are also implicated in osteoporosis development.

    Purpose of the Study:

    • To review the clinical features of bone loss associated with corticosteroids, heparin, and methotrexate.
    • To explore the pathophysiologic mechanisms underlying drug-induced bone loss.
    • To outline strategies for preventing osteoporosis in patients using these medications.

    Main Methods:

    • Literature review of studies on drug-induced bone loss.
    • Analysis of clinical features and mechanisms of osteoporosis.
    • Synthesis of prevention and management strategies.

    Main Results:

    • Corticosteroids are frequently associated with significant bone loss.
    • Heparin and methotrexate, particularly at high doses, are linked to osteoporosis.
    • Understanding the mechanisms can guide preventative measures.

    Conclusions:

    • Awareness of bone loss risks associated with corticosteroids, heparin, and methotrexate is crucial.
    • Implementing preventative strategies can mitigate the development of osteoporosis.
    • Further research into optimizing treatment regimens to minimize bone complications is warranted.

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