Carbohydrates in diversity-oriented synthesis: challenges and opportunities

Area of Science:

• Organic Chemistry
• Medicinal Chemistry
• Chemical Biology

Background:

• Diversity-Oriented Synthesis (DOS) is a key strategy for generating diverse small molecule libraries.
• These libraries serve as probes for investigating biological pathways and expanding chemical space.
• Drug discovery and chemical biology benefit from DOS approaches for target and ligand identification.

Purpose of the Study:

• To review the application of carbohydrate chemistry in Diversity-Oriented Synthesis.
• To explore how carbohydrates contribute to accessible chemical space through diversity.
• To discuss research contributions and future perspectives in this field.

Main Methods:

• Utilizing carbohydrates as versatile building blocks for DOS.
• Leveraging the stereochemical diversity and functional groups of carbohydrates.
• Focusing on appendage, stereochemical, and scaffold diversity in library design.

Main Results:

• Carbohydrates offer a rich platform for creating structurally complex and diverse molecules.
• DOS strategies with carbohydrates enhance the exploration of chemical space.
• This approach facilitates advances in drug discovery and chemical biology.

Conclusions:

• Carbohydrate-based DOS is a powerful strategy for generating molecular diversity.
• It significantly contributes to expanding the chemical space for biological investigation.
• This review highlights the potential and ongoing research in carbohydrate-driven DOS.