Related Experiment Video
Updated: Mar 29, 2026

Methane Hydrate Crystallization on Sessile Water Droplets
Published on: May 26, 2021
Mometasone furoate revisited, or how did the hydrate get in the bottle?
1Massachusetts Institute of Technology, Massachusetts Avenue 2-325, Cambridge, MA 02139, USA.
Abstract:
The redetermined structure of 9α,21-dichloro-11β,17α-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-17-yl furan-2-carboxylate monohydrate, C27H32Cl2O7·H2O, at 100 K has triclinic (P1) symmetry. The structure displays O-H...O hydrogen bonding, which gives rise to infinite sheets extending parallel to the [110] plane. The previously published structure [Chen et al. (2005). J. Pharm. Sci. 94, 2496-2509] was determined at room temperature and no significant anomalous signal was present. Data for the structure presented in this study were collected at low temperature and the absolute configuration could be established based solely on anomalous diffraction. Another point of interest is that the structure determined in this study is that of the monohydrate, even though the crystal was harvested from a bottle of nasal spray that was supposed to contain exclusively crystals of the anhydrous form.
More Related Videos
08:12Surface Functionalization of Metal-Organic Frameworks for Improved Moisture Resistance
Published on: September 5, 2018
12:05Preparation of Hydrophobic Metal-Organic Frameworks via Plasma Enhanced Chemical Vapor Deposition of Perfluoroalkanes for the Removal of Ammonia
Published on: October 10, 2013
Related Concept Videos
Aldehydes and Ketones with Water: Hydrate Formation
The formation of hydrates is a reversible reaction. Hydrate formation is influenced by steric and electronic factors accompanying the alkyl substituents on the carbonyl group: The rate of hydrate formation increases with a decrease in the number of alkyl groups attached to the carbonyl carbon. Hence,...
Regioselectivity and Stereochemistry of Acid-Catalyzed Hydration
Multiple Halogenation of Methyl Ketones: Haloform Reaction
Alkynes to Aldehydes and Ketones: Acid-Catalyzed Hydration
Analogous to alkenes, alkynes also undergo acid-catalyzed hydration. While the addition of water to an alkene gives an alcohol, hydration of alkynes produces different products such as aldehydes and ketones.
Ionic Compounds: Formulas and Nomenclature
Hydroboration-Oxidation of Alkenes