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Updated: Mar 29, 2026
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A Melanoma Patient-Derived Xenograft Model
Published on: May 20, 2019
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Psoriasis in melanoma patients: a prospective pilot study
Matteo Megna1, Maddalena Napolitano2, Nicola Balato1
1Section of Dermatology, Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Summary
Psoriasis may protect against melanoma development. This study found melanoma patients had less psoriasis history, while psoriatic patients showed lower melanoma incidence, suggesting an inverse relationship.
Area of Science:
- Immunology
- Dermatology
- Oncology
Background:
- Melanoma is an immunogenic tumor where T-cell infiltrates correlate with survival.
- Psoriasis is a T-cell mediated inflammatory disease.
- Understanding the interplay between these conditions is crucial.
Purpose of the Study:
- To investigate the relationship between melanoma and psoriasis.
- To compare melanoma patients (MG), psoriasis patients (PG), and controls (CG).
Main Methods:
- Prospective pilot study design.
- Clinical examination and detailed patient history.
- Gene expression analysis of IL-6, IFN-γ, and TNF-α in all groups.
Main Results:
- Melanoma patients had lower psoriasis and family history of psoriasis frequencies than controls.
- Psoriasis patients had fewer melanocytic nevi (MN) and lower family history of melanoma frequency than controls.
- Interleukin-6 (IL-6) and Interferon-gamma (IFN-γ) were elevated in psoriasis patients and reduced in melanoma patients.
Conclusions:
- A potential inverse relationship between psoriasis and melanoma development is suggested.
- Psoriasis may have a protective role against melanoma.
