Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Tumor Microenvironment02:17

The Tumor Microenvironment

8.1K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
8.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Gut Microbiota as a Key Modulator in the Pathophysiology of Sepsis: SURVEIL Project.

MicrobiologyOpen·2026
Same author

Gut microbiota and metabolome signatures in obese and normal-weight patients with colorectal tumors.

iScience·2025
Same author

Characterization of gut microbiota dynamics in an Alzheimer's disease mouse model through clade-specific marker-based analysis of shotgun metagenomic data.

Biology direct·2024
Same author

Pilot, open-label, randomized controlled clinical trial evaluating 4 oral hygiene regimens using a manual toothbrush, toothpaste, and mouthwash.

General dentistry·2024
Same author

A Randomized, Double-Blind, Placebo-Controlled Trial: Efficacy of <i>Opuntia ficus</i>-<i>indica</i> Prebiotic Supplementation in Subjects with Gut Dysbiosis.

Nutrients·2024
Same author

Distinct Signatures of Tumor-Associated Microbiota and Metabolome in Low-Grade vs. High-Grade Dysplastic Colon Polyps: Inference of Their Role in Tumor Initiation and Progression.

Cancers·2023

Related Experiment Video

Updated: Mar 29, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

10.2K

The Microenvironment in Gliomas: Phenotypic Expressions.

Davide Schiffer1, Laura Annovazzi2, Marta Mazzucco3

  • 1Research Center, Policlinico di Monza Foundation, Via Pietro Micca 29, 13100 Vercelli, Italy. davide.schiffer@unito.it.

Cancers
|December 4, 2015
PubMed
Summary

Malignant glioma microenvironments contain diverse stromal cells and molecular signals. Tumor stem cells may arise from reprogramming within specific niches, challenging traditional views.

Keywords:
microenvironmentnichesstem cells

More Related Videos

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.8K
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.4K

Related Experiment Videos

Last Updated: Mar 29, 2026

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections
05:45

Quantitative Immunohistochemistry of the Cellular Microenvironment in Patient Glioblastoma Resections

Published on: July 31, 2017

10.2K
Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma
09:17

Digital Spatial Profiling for Characterization of the Microenvironment in Adult-Type Diffusely Infiltrating Glioma

Published on: September 13, 2022

2.8K
Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures
06:32

Evaluation of Biomarkers in Glioma by Immunohistochemistry on Paraffin-Embedded 3D Glioma Neurosphere Cultures

Published on: January 9, 2019

8.4K

Area of Science:

  • Neuro-oncology
  • Cancer Biology
  • Tumor Microenvironment Research

Background:

  • Malignant gliomas possess a complex microenvironment comprising tumor cells and various stromal cells.
  • Key functional components include intricate molecular signaling networks.
  • Perivascular and perinecrotic niches are hypothesized to harbor glioma stem cells.

Purpose of the Study:

  • To critically revise the conceptual understanding of glioma microenvironment niches.
  • To explore an alternative interpretation of perinecrotic niche origins.
  • To investigate the dynamic nature of stem-like characteristics in glioma cells.

Main Methods:

  • Literature review and critical analysis of existing definitions.
  • Conceptual re-evaluation of perivascular and perinecrotic niches.
  • Exploration of cell reprogramming mechanisms within the tumor microenvironment.

Main Results:

  • Stromal cells like microglia, pericytes, and astrocytes are integral to the glioma microenvironment.
  • An alternative model suggests perinecrotic niches arise from residual cells in necrotic areas.
  • Stem-like properties are presented as a dynamic status regulated by microenvironmental reprogramming.

Conclusions:

  • The concept of glioma stem cells as a distinct cell type is challenged.
  • Microenvironmental reprogramming is proposed as a key mechanism for generating stem-like cells.
  • A revised understanding of glioma niches may impact therapeutic strategies.