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Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
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Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
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Hs-CRP in stroke: A meta-analysis.

Yongjing Zhou1, Wei Han2, Dandan Gong1

  • 1Institute of Molecular Biology & Translational Medicine, the Affiliated People's Hospital, Jiangsu University, Zhenjiang, Jiangsu 212002, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|December 4, 2015
PubMed
Summary
This summary is machine-generated.

Elevated high-sensitivity C-reactive protein (hs-CRP) is linked to increased ischemic stroke risk. This meta-analysis found no clear association between hs-CRP and hemorrhagic stroke risk.

Keywords:
Hemorrhagic strokeHigh-sensitivity C-reactive proteinIschemic strokeMeta-analysisStroke

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Area of Science:

  • Cardiovascular Medicine
  • Neuroscience
  • Biomarkers

Background:

  • Conflicting evidence exists regarding the association between high-sensitivity C-reactive protein (hs-CRP) and stroke risk.
  • Understanding this relationship is crucial for stroke prevention strategies.

Purpose of the Study:

  • To conduct a meta-analysis to determine if elevated baseline hs-CRP is an independent risk factor for different stroke subtypes.
  • To provide a comprehensive assessment of hs-CRP's role in stroke etiology.

Main Methods:

  • Systematic search of multiple databases (PubMed, Embase, Cochrane Library, CNKI, Wanfang) for prospective observational studies.
  • Inclusion of studies reporting hs-CRP levels and adjusted risk estimates for stroke subtypes.
  • Pooled analysis using fixed-effect model to calculate adjusted risk ratios (RRs) and 95% confidence intervals (CIs).

Main Results:

  • Twelve studies with 66,560 participants and 2269 stroke events were analyzed.
  • Elevated hs-CRP was associated with a significantly increased risk of ischemic stroke (RR 1.46, 95% CI 1.27-1.67).
  • No significant association was found between hs-CRP and hemorrhagic stroke risk (RR 0.82, 95% CI 0.59-1.13).

Conclusions:

  • Elevated baseline hs-CRP levels are an independent risk factor for ischemic stroke.
  • Hs-CRP does not appear to be clearly associated with hemorrhagic stroke risk.
  • Findings highlight the potential role of hs-CRP as a biomarker for ischemic stroke prediction.