Related Experiment Video

Updated: Mar 29, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction
09:20

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

7.2K

New Insights in the Diagnosis and Treatment of Heart Failure

Giulio Agnetti1, Massimo F Piepoli2, Giuseppe Siniscalchi3

  • 1Division of Cardiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA ; DIBINEM, University of Bologna, 40126 Bologna, Italy.

Biomed Research International
|December 4, 2015
PubMed

Insights

Innovative treatments are being explored for heart failure patients who do not respond to standard therapies and are ineligible for heart transplantation. This review assesses novel diagnostic and therapeutic strategies for end-stage heart disease survivors.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Transplantation Medicine

Background:

  • Cardiovascular disease, particularly ischemic heart disease, is a primary cause of mortality in Western countries.
  • Advances in acute coronary syndrome treatment increase survival rates, leading to a rise in heart failure cases.
  • Heart transplantation is the gold standard for end-stage heart failure but limited by donor organ availability.

Purpose of the Study:

  • To review the safety and efficacy of innovative diagnostic methods for heart failure.
  • To evaluate novel therapeutic strategies for patients refractory to standard medical care.
  • To assess approaches for patients excluded from cardiac transplantation lists.

Main Methods:

  • Literature review of recent studies on advanced heart failure diagnosis.
  • Analysis of clinical trial data for innovative heart failure treatments.
  • Evaluation of patient outcomes in refractory heart failure cases.

Main Results:

  • Emerging diagnostic tools show promise in identifying advanced heart failure.
  • Several innovative therapies demonstrate potential benefits for non-transplant candidates.
  • Safety profiles of new interventions require further rigorous investigation.

Conclusions:

  • Novel approaches offer hope for patients with advanced heart failure ineligible for transplantation.
  • Continued research is crucial to validate the efficacy and safety of these innovative strategies.
  • Expanding treatment options is vital for improving outcomes in refractory heart failure populations.

More Related Videos

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs07:09

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs

Published on: February 18, 2022

2.5K
Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach07:49

Author Spotlight: Investigating HR-Dependent Cardiac Function in Mouse Models Through a Novel Atrial-Pacing Approach

Published on: July 21, 2023

2.1K

Related Concept Videos

Heart Failure IV: Classification and Diagnostic Evaluation01:30

Heart Failure IV: Classification and Diagnostic Evaluation

Heart failure can be classified in various ways, with the most common classifications based on physical activity limitations, disease progression, severity, and treatment strategies.The Functional Classification of Heart Failure divides patients into four categories based on physical activity limitation due to symptom burden.Class I: Patients in this class have cardiac disease but no physical activity limitations. Ordinary activities like walking, climbing stairs, or routine tasks do not cause...
585
Heart Failure VII: Nursing Interventions01:30

Heart Failure VII: Nursing Interventions

The first step in nursing management of a patient with heart failure involves thoroughly assessing the patient's medical history.Subjective Data: Obtain the patient's medical history of coronary artery disease, hypertension, myocardial infarction, and symptoms like dyspnea, orthopnea, and paroxysmal nocturnal dyspnea.Objective Data: Conduct a physical examination to identify findings such as jugular vein distention, pulmonary crackles, tachycardia, murmurs, peripheral edema, and vital signs,...
705
Heart Failure V: Medical Management01:30

Heart Failure V: Medical Management

Medical Management of Acute Decompensated Heart Failure (ADHF)The primary goals of therapy for patients hospitalized with acute decompensated heart failure (ADHF) include:Relieving symptomsOptimizing volume statusSupporting oxygenation and ventilationMaintaining cardiac output (CO) and end-organ perfusionIdentifying and addressing the cause of ADHFPreventing complicationsProviding patient education on factors precipitating HF exacerbationPlanning for dischargeOngoing monitoring and assessment...
520
Heart Failure VI: Adjunct Therapies01:22

Heart Failure VI: Adjunct Therapies

Additional therapies for treating patients with heart failure (HF) may include procedural interventions, supplemental oxygen, the management of sleep disorders, and nutritional therapy.Procedural InterventionsImplantable Cardioverter-Defibrillator: For patients at risk of life-threatening arrhythmias due to severe left ventricular dysfunction, an Implantable Cardioverter-Defibrillator (ICD) can detect and terminate these arrhythmias, preventing sudden cardiac death and improving survival rates.
557
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
634
Rheumatic Heart Disease III: Medical Management01:21

Rheumatic Heart Disease III: Medical Management

Rheumatic heart disease (RHD) management can be divided into two main strategies: prevention and long-term management.Primary PreventionPrimary prevention focuses on timely diagnosis and management of group A streptococcal pharyngitis to prevent acute rheumatic fever. The most widely used antibiotic for treating this condition is intramuscular benzathine penicillin G.Acute Rheumatic Fever TreatmentThe primary treatment goal for a patient diagnosed with acute rheumatic fever is to suppress the...
490