Related Experiment Video

Updated: Mar 29, 2026

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.9K

Relationship between perioperative cardiovascular risk factors and bone marrow cells from patients undergoing

L Zhang1, R Wang1, C-S Xiao1

  • 1Department of Cardiovascular Surgery, PLA General Hospital Beijing, Beijing, China.

Genetics and Molecular Research : GMR
|December 5, 2015
PubMed

Insights

Aging and diabetes significantly reduce bone marrow progenitor cells in patients with coronary heart disease. These factors may impact the success of cell therapy for ischemic heart disease, necessitating further investigation.

Area of Science:

  • Cardiovascular Medicine
  • Regenerative Medicine
  • Hematology

Background:

  • Autologous bone marrow cell therapy is explored for ischemic heart disease.
  • Patient outcomes vary, highlighting the need to identify predictive risk factors.
  • Understanding bone marrow progenitor cell levels and function is crucial for patient selection.

Purpose of the Study:

  • To identify risk factors influencing bone marrow progenitor cell levels and function in patients undergoing coronary artery bypass grafting (CABG).
  • To assess the impact of age, diabetes, and gender on bone marrow mononuclear cells (BMMNCs) and their progenitor cell populations (CD34+, CD133+).

Main Methods:

  • Collected clinical and laboratory data from 44 patients undergoing CABG.
  • Isolated BMMNCs from sternal bone marrow aspirates.
  • Analyzed BMMNC counts, CD34+, CD133+, and CD34+CD133+ cell levels.
  • Assessed progenitor cell clonogenic function and BMMNC migration ability.

Main Results:

  • A significant negative correlation was found between BMMNC count and patient age (r = -0.788, P = 0.001).
  • Diabetic patients exhibited significantly lower levels of CD34+ and CD133+ cells compared to non-diabetic patients.
  • Female gender, advanced age, and poor heart function were associated with reduced progenitor cell clonogenic function.
  • Higher CD34+ cell levels correlated positively with BMMNC migration ability.

Conclusions:

  • Aging and diabetes are identified as major risk factors affecting the level and function of bone marrow progenitor cells in coronary heart disease patients.
  • These findings suggest that age and diabetes may influence the efficacy of bone marrow cell therapy for ischemic heart disease.
  • Further research is warranted to confirm the impact of these risk factors on therapeutic outcomes.

More Related Videos

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

3.4K
Author Spotlight: Enhancing Coronary Artery Revascularization05:25

Author Spotlight: Enhancing Coronary Artery Revascularization

Published on: September 15, 2023

1.4K

Related Concept Videos

Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
424
Peripheral Artery Disease V: Postoperative Nursing Management01:23

Peripheral Artery Disease V: Postoperative Nursing Management

During the postoperative period, it is crucial to focus on maintaining circulation, identifying and managing potential complications, and planning for discharge.Nursing AssessmentVital signs monitoring: Regularly monitor vital signs, including blood pressure, heart rate, respiratory rate, and temperature, to detect early signs of complications such as bleeding and infection.Circulation assessment: Monitor pulses, perform Doppler assessments, and check capillary refill, color, temperature, and...
566
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
2.4K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
5.1K
Blood and Nerve Supply to the Bones01:29

Blood and Nerve Supply to the Bones

Bones are dynamic organs that require a rich supply of oxygen and nutrients. Around 5% to 10% of the cardiac output supplies blood to the bones. A typical long bone has three main sources: the nutrient artery, the metaphyseal and epiphyseal arteries, and the periosteal arteries.
Nutrient Artery
The nutrient artery is the main blood vessel that enters the diaphysis via the nutrient foramen. While most long bones have only one nutrient foramen, large bones, such as the femur, may have two. This...
14.6K
Aneurysm IV: Nursing Management01:22

Aneurysm IV: Nursing Management

Vigilant monitoring for aneurysm rupture is essential for patients undergoing aortic surgery.Preoperative Nursing ManagementContinuously monitor the patient for manifestations of aneurysm rupture, such as pallor, weakness, tachycardia, hypotension, abdominal, back, groin, or periumbilical pain, changes in consciousness, and a pulsating abdominal mass. Regularly assess the patient's peripheral pulses.Instruct the patient to consume a clear liquid diet the day before surgery and administer...
582