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CYSTIC FIBROSIS AND ANTIBIOTIC HYPERSENSITIVITY: PRESENT KNOWLEDGE AND PRACTICAL APPROACH
D Caimmi1, R Chiron1, F Tremblay2
1Department of Pediatrics, Hôpital Arnaud de Villeneuve, University Hospital of Montpellier, France.
Journal of Biological Regulators and Homeostatic Agents
|December 5, 2015
Summary
Cystic fibrosis, a genetic disease affecting the CFTR protein, often leads to lung infections and antibiotic hypersensitivity. Allergy work-ups and desensitization can help manage these complications, improving patient quality of life.
Area of Science:
- Genetics
- Pulmonology
- Immunology
Background:
- Cystic fibrosis is a common fatal genetic disorder caused by mutations in the CFTR gene.
- It affects multiple organs, with respiratory complications being most frequent.
- Patients frequently develop hypersensitivity reactions to antibiotics due to recurrent infections.
Purpose of the Study:
- To highlight the challenges of antibiotic hypersensitivity in cystic fibrosis patients.
- To emphasize the importance of accurate allergy diagnosis.
- To discuss desensitization as a therapeutic option.
Main Methods:
- Review of cystic fibrosis pathophysiology and complications.
- Discussion of diagnostic approaches for antibiotic hypersensitivity.
- Evaluation of desensitization protocols.
Main Results:
- Over 2000 CFTR mutations are known, impacting disease presentation.
- Recurrent lung infections are a major cause of progressive lung function loss.
- Comprehensive allergy work-ups are crucial for identifying true hypersensitivity.
Conclusions:
- Antibiotic hypersensitivity is a significant concern for cystic fibrosis patients.
- Accurate diagnosis via clinical history, skin tests, and provocation tests is essential.
- Desensitization offers a viable strategy to enable necessary antibiotic treatments for allergic patients.
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