Related Experiment Video
Updated: Mar 29, 2026
08:58
Analyzing Beneficial Effects of Nutritional Supplements on Intestinal Epithelial Barrier Functions During Experimental Colitis
Published on: January 5, 2017
13.0K
PROBIOTICS AND INFLAMMATORY BOWEL DISEASES
A Ricci1, S C Tagliacarne2, C Valsecchi2
1Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.
Journal of Biological Regulators and Homeostatic Agents
|December 5, 2015
Summary
Gut bacteria play a role in immune balance. In Inflammatory Bowel Disease (IBD), beneficial butyrate-producing bacteria like Faecalibacterium Prausnitzii are often reduced, potentially worsening chronic inflammation.
Area of Science:
- Gastroenterology and Immunology
- Microbiome Research
Background:
- The gut microbiota comprises beneficial bacteria and pathobionts.
- Specific microbes influence gut immunological equilibrium via immune cell interactions.
- Dysregulated gut-associated interactions are implicated in Inflammatory Bowel Disease (IBD) pathogenesis.
Purpose of the Study:
- To explore the role of specific gut bacteria in maintaining immune homeostasis.
- To investigate the association between gut microbiota composition and Inflammatory Bowel Disease (IBD).
Main Methods:
- Analysis of intestinal microbiota composition.
- Assessment of gut barrier function.
- Evaluation of the intestinal immune system.
Main Results:
- Certain butyrate-producing bacteria, including Faecalibacterium Prausnitzii, are underrepresented in IBD patients.
- This reduction may correlate with the chronic inflammatory state observed in IBD.
Conclusions:
- Alterations in gut microbiota composition, particularly a decrease in beneficial bacteria, are linked to IBD.
- Faecalibacterium Prausnitzii may play a protective role against chronic gut inflammation.
Related Concept Videos
01:30Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
1.0K
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
1.0K
01:22Probiotics
174
Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
174
01:29Inflammatory Bowel Disease IV: Pharmacological Management
935
Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
Pharmacologic...
935
01:17Irritable Bowel Syndrome I: Introduction
1.4K
Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
1.4K
01:27Inflammatory Bowel Disease I: Ulcerative Colitis
1.4K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.4K
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.5K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.5K