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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Probiotics are live, non-pathogenic microorganisms that confer health benefits by modulating the gut microbiota. The human gastrointestinal tract harbors a complex microbial ecosystem, and the balance of this microbiota is crucial for digestive and systemic health. Among the most extensively studied and utilized probiotics are species formerly classified within the genera Lactobacillus and Bifidobacterium. These organisms not only naturally colonize the human gut but are also consumed through...
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Inflammatory Bowel Disease IV: Pharmacological Management01:29

Inflammatory Bowel Disease IV: Pharmacological Management

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Upon diagnosis, managing Inflammatory Bowel Disease (IBD) involves addressing several crucial aspects. The primary goals include resting the bowel, correcting malnutrition, and providing symptomatic relief. Resting the bowel may consist of medications to reduce inflammation and promote healing. Correcting malnutrition is essential, often requiring dietary adjustments and nutritional supplements. Symptomatic relief aims to ease pain, diarrhea, and other discomforts in IBD.
Pharmacologic...
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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
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Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Inflammatory Bowel Disease II: Crohn's Disease01:30

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Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
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PROBIOTICS AND INFLAMMATORY BOWEL DISEASES.

A Ricci1, S C Tagliacarne2, C Valsecchi2

  • 1Department of Pediatrics, IRCCS Policlinico San Matteo Foundation, Pavia, Italy.

Journal of Biological Regulators and Homeostatic Agents
|December 5, 2015
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Summary

Gut bacteria play a role in immune balance. In Inflammatory Bowel Disease (IBD), beneficial butyrate-producing bacteria like Faecalibacterium Prausnitzii are often reduced, potentially worsening chronic inflammation.

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Area of Science:

  • Gastroenterology and Immunology
  • Microbiome Research

Background:

  • The gut microbiota comprises beneficial bacteria and pathobionts.
  • Specific microbes influence gut immunological equilibrium via immune cell interactions.
  • Dysregulated gut-associated interactions are implicated in Inflammatory Bowel Disease (IBD) pathogenesis.

Purpose of the Study:

  • To explore the role of specific gut bacteria in maintaining immune homeostasis.
  • To investigate the association between gut microbiota composition and Inflammatory Bowel Disease (IBD).

Main Methods:

  • Analysis of intestinal microbiota composition.
  • Assessment of gut barrier function.
  • Evaluation of the intestinal immune system.

Main Results:

  • Certain butyrate-producing bacteria, including Faecalibacterium Prausnitzii, are underrepresented in IBD patients.
  • This reduction may correlate with the chronic inflammatory state observed in IBD.

Conclusions:

  • Alterations in gut microbiota composition, particularly a decrease in beneficial bacteria, are linked to IBD.
  • Faecalibacterium Prausnitzii may play a protective role against chronic gut inflammation.