Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Antiasthma Drugs: Leukotriene Modifiers01:19

Antiasthma Drugs: Leukotriene Modifiers

2.2K
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
2.2K
Asthma-IV: Diagnostic and Management01:30

Asthma-IV: Diagnostic and Management

3.3K
The diagnosis and management of asthma are comprehensive, encompassing clinical assessments, lung function tests, and pharmacological interventions. Here's an overview:
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
3.3K
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

3.6K
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.6K
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

2.3K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
2.3K
Asthma-IV: Nursing Management01:30

Asthma-IV: Nursing Management

4.0K
The nursing management of asthma is a comprehensive approach that relies heavily on the expertise and dedication of healthcare professionals. It involves thorough assessment, accurate diagnosis, strategic planning, effective implementation, and diligent evaluation. By meticulously following this step-by-step process, healthcare professionals play a crucial role in providing the best possible care and treatment for patients with asthma, enhancing their overall health and well-being.
First, in...
4.0K
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

1.7K
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
1.7K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Meat quality of a slow-growing chicken breed fed soybean meal-free diets.

Animal : an international journal of animal bioscience·2026
Same author

Correction: Robotic uterine transposition for fertility preservation in patients undergoing pelvic radiotherapy: a narrative review of surgical evolution, technical strategies, and emerging evidence.

Journal of robotic surgery·2026
Same author

Robotic uterine transposition for fertility preservation in patients undergoing pelvic radiotherapy: a narrative review of surgical evolution, technical strategies, and emerging evidence.

Journal of robotic surgery·2026
Same author

Specific hepatic gene responses to dietary fat levels during the finisher phase in a slow-growing chicken breed.

Poultry science·2025
Same author

Quantifying Memory in Spin Glasses.

Physical review letters·2025
Same author

Aesthetic perception of patient in developmental age in interceptive orthodontic treatment.

European journal of paediatric dentistry·2024

Related Experiment Video

Updated: Mar 29, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.6K

SERUM YKL-40 IN CHILDREN WITH ASTHMA.

S Leonardi1, M Filippelli1, A Lanzafame1

  • 1Department of Clinical and Experimental Medicine, Unit of Pediatric Pneumoallergology and Cystic Fibrosis, University of Catania, Catania, Italy.

Journal of Biological Regulators and Homeostatic Agents
|December 5, 2015
PubMed
Summary
This summary is machine-generated.

Elevated serum YKL-40 levels indicate asthma in children. This chitinase-like protein shows promise as a biomarker for childhood asthma, aiding in diagnosis beyond clinical assessments.

More Related Videos

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.7K

Related Experiment Videos

Last Updated: Mar 29, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

10.6K
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.1K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.7K

Area of Science:

  • Pediatric Pulmonology
  • Biomarker Discovery
  • Clinical Immunology

Background:

  • Asthma diagnosis in children relies on clinical history and lung function tests, which can be non-specific and insensitive.
  • New biomarkers for airway inflammation are needed to improve diagnostic accuracy.
  • YKL-40, a chitinase-like protein, is implicated in inflammation and tissue remodeling in various diseases.

Purpose of the Study:

  • To evaluate serum YKL-40 levels in children diagnosed with intermittent or persistent asthma.
  • To determine if YKL-40 can serve as a diagnostic biomarker for childhood asthma.

Main Methods:

  • Cross-sectional analysis of serum samples from pediatric asthma patients and healthy controls.
  • Stratification of asthma patients into mild intermittent, mild persistent, moderate persistent, and severe persistent categories.
  • Quantification of serum YKL-40 using a commercially available enzyme-linked immune-adsorbent assay (ELISA) kit.

Main Results:

  • Circulating YKL-40 levels were significantly higher in children with asthma compared to healthy controls (36±18.6 vs 14.41±2.88, p=0.001).
  • Significantly elevated YKL-40 values were observed in both intermittent and persistent asthma groups compared to controls (p<0.001).
  • No significant correlation was found between YKL-40 levels and asthma duration or severity.

Conclusions:

  • Serum YKL-40 is a potential biomarker for asthma in children.
  • YKL-40 levels are elevated in children with both intermittent and persistent asthma.
  • Further research may validate YKL-40 as a diagnostic tool for pediatric asthma.