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Leonuketal, a Spiroketal Diterpenoid from Leonurus japonicus
Liang Xiong, Qin-Mei Zhou, Yike Zou1
1Department of Chemistry, University of Pennsylvania , 231 South 34 Street, Philadelphia, Pennsylvania 19104-6323, United States.
Abstract:
An architecturally complex spiroketal diterpenoid, leonuketal (1), was isolated from the aerial parts of the plant Leonurus japonicus. This compound possessed an unprecedented tetracyclic skeleton that comprised a bridged spiroketal moiety fused with a ketal-γ-lactone unit. The structure and absolute configuration were determined by spectroscopic analyses, a modified Mosher's method, and ECD (electronic circular dichroism) calculations. Leonuketal (1) showed significant vasorelaxant activity against KCl-induced contraction of rat aorta, with the EC50 value of 2.32 μM.
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