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Updated: Mar 29, 2026

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing
Published on: August 14, 2019
Adherence and Persistence Patterns in Medication Use Among Men With Lower Urinary Tract Symptoms/Benign Prostatic
Emily Shortridge1, Craig Donatucci1, Prina Donga2
11 Eli Lilly and Company, Indianapolis, IN, USA.
Patients with lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) demonstrated high medication adherence and persistence. Many patients remained on therapy for over four years, indicating effective symptom management.
Area of Science:
- Urology
- Pharmacology
- Health Services Research
Background:
- Lower urinary tract symptoms/benign prostatic hyperplasia (LUTS/BPH) are common in aging men.
- Medication adherence and persistence are crucial for managing chronic conditions like LUTS/BPH.
- Understanding patient treatment patterns is essential for optimizing care.
Purpose of the Study:
- To analyze medication adherence and persistence patterns in patients diagnosed with LUTS/BPH.
- To evaluate the duration of therapy and factors influencing long-term treatment in this patient population.
Main Methods:
- Retrospective analysis of electronic medical records from Reliant Medical Group.
- Inclusion of 1,807 patients with LUTS/BPH, with 97% aged 50 years or older.
- Evaluation of prescription data, including index prescriptions and filled prescriptions over time.
Main Results:
- 48% of patients persisted on index therapy for four years or longer.
- The mean number of filled prescriptions per patient was 6.26.
- Patients on combination therapy (alpha-blocker and 5-alpha reductase inhibitor) showed particularly high adherence and persistence.
Conclusions:
- Patients with LUTS/BPH exhibit favorable medication adherence and persistence rates.
- Effective symptom relief likely contributes to sustained treatment adherence and persistence.
- Combination therapy may enhance long-term treatment compliance in LUTS/BPH management.
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