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Mitral valve prolapse in Turner syndrome
V Bastianon1, A M Pasquino, E Giglioni
1Division of Cardiology, University of Rome La Sapienza, Italy.
European Journal of Pediatrics
|April 1, 1989
Summary
This study found a higher incidence of mitral valve prolapse in patients with Turner syndrome compared to the general population. These findings highlight the importance of cardiac monitoring for individuals with Turner syndrome.
Area of Science:
- Cardiology
- Genetics
- Pediatrics
Background:
- Turner syndrome is a genetic condition affecting females.
- Cardiac abnormalities are common in Turner syndrome.
- Previous research suggests a potential link between Turner syndrome and valvular heart disease.
Purpose of the Study:
- To investigate the prevalence of specific cardiac abnormalities in patients with Turner syndrome.
- To compare the incidence of mitral valve prolapse in Turner syndrome patients to the general population.
Main Methods:
- Clinical examination of 46 patients with Turner syndrome.
- M-mode and two-dimensional echocardiography.
- Dynamic exercise testing and 24-hour Holter monitoring.
Main Results:
- Twelve patients (26.1%) exhibited mitral valve prolapse.
- Seven patients (15.2%) had isolated non-stenotic bicuspid aortic valve.
- Aortic root dilation was observed in 2 patients (4.3%).
- The incidence of mitral valve prolapse was significantly higher in Turner syndrome patients (P < 0.025).
Conclusions:
- Mitral valve prolapse occurs significantly more frequently in individuals with Turner syndrome.
- These findings underscore the need for thorough cardiac evaluation in Turner syndrome management.
- Further research may explore the underlying mechanisms linking Turner syndrome to valvular heart disease.