[Effect of metatsin on digestive enzyme activity]

The effect of a peripheral cholinergic blocking agent on the activity of some digestive enzymes involved in protein hydrolysis was studied on albino rats under normal conditions and during stress. Metacine was administered orally. Single doses were 100, 200 and 300 mg/kg. At long-term administration and in the subsequent series of experiments the dose was 200 mg/kg. The experiments showed that the drug treatment produced significant changes in the activity of digestive enzymes involved in protein hydrolysis. A preliminary administration of metacine was found to smooth out the changes in the activity of the enzymes observed under conditions of immobilization and hyperthermia.