Related Experiment Video
Updated: Mar 29, 2026

07:49
Measuring Local Anaphylaxis in Mice
Published on: October 14, 2014
20.2K
Backward- and Forward-Looking Potential of Anaphors
Petra B Schumacher1, Jana Backhaus1, Manuel Dangl1
1Department of German Language and Literature I, University of Cologne Cologne, Germany.
Frontiers in Psychology
|December 5, 2015
Summary
Personal pronouns maintain topics, while demonstratives signal shifts. Prominence cues like thematic role guide pronoun processing, impacting mental models and discourse functions.
Area of Science:
- Psycholinguistics
- Cognitive Neuroscience
- Computational Linguistics
Background:
- Personal pronouns and demonstratives serve distinct discourse functions.
- Pronouns encode information differently in mental models.
- Backward-looking pronouns maintain topic; forward-looking pronouns signal shifts.
Purpose of the Study:
- Investigate processing differences between personal (er) and demonstrative (der) pronouns in German.
- Assess the impact of antecedent prominence (thematic role, position) on pronoun comprehension.
- Examine neurophysiological correlates of backward- and forward-looking functions.
Main Methods:
- Event-related potential (ERP) study with German pronouns (er vs. der).
- Manipulation of verb type and thematic role order to vary antecedent prominence.
- Experiment 2: Story continuation task to assess topic maintenance vs. shift.
Main Results:
- Demonstrative pronouns elicited a biphasic N400-Late Positivity compared to personal pronouns.
- Antecedent prominence, guided by thematic role and position, influenced processing.
- Personal pronouns maintained topic; demonstrative pronouns induced topic shifts.
Conclusions:
- Antecedent prominence calculation relies on thematic role and positional information.
- Referencing less prominent entities with demonstratives incurs processing costs (N400).
- Demonstratives signal topic shifts, leading to attentional reorienting (Late Positivity).
Related Concept Videos
Allergic Reactions
33.6K
Overview
33.6K
Allergic Reactions: Anaphylaxis
172
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
172
Cross-reactivity
33.8K
Overview
33.8K
Desensitization and Tachyphylaxis
3.4K
Tachyphylaxis is described as a rapid decrease in response to a drug after repeated or continuous administration of the same drug dose. It is a phenomenon where the body becomes less responsive to a particular substance or intervention over time, requiring higher doses or stronger interventions to achieve the same effect. It results from adaptive changes in the body's receptors, signaling pathways, or physiological processes that occur in response to prolonged exposure to a stimulus.
3.4K
Hypersensitivities
8.3K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
8.3K
Pharmacovigilance
1.9K
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
1.9K

