Related Experiment Video

Updated: Mar 29, 2026

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries
08:58

En Face Detection of Nitric Oxide and Superoxide in Endothelial Layer of Intact Arteries

Published on: February 25, 2016

10.2K

Serum Superoxide Dismutase Is Associated with Vascular Structure and Function in Hypertensive and Diabetic Patients

Manuel A Gómez-Marcos1, Ana M Blázquez-Medela2, Luis Gamella-Pozuelo2

  • 1Research Unit, Primary Care Centre La Alamedilla, SACYL, Avenida de los Comuneros 27, 37003 Salamanca, Spain.

Oxidative Medicine and Cellular Longevity
|December 5, 2015
PubMed

Insights

Serum superoxide dismutase (SOD) levels correlate with vascular changes in hypertensive and diabetic patients. Lower SOD indicates poorer vascular health, highlighting its role as a cardiovascular risk marker.

Area of Science:

  • Cardiovascular Medicine
  • Biochemistry
  • Endocrinology

Background:

  • Oxidative stress contributes to cardiovascular diseases like hypertension and atherosclerosis.
  • Superoxide dismutase (SOD) is a key intracellular antioxidant defense mechanism.
  • Existing research links vascular parameters to cardiovascular risk, but SOD's role in hypertensive and diabetic patients is unexplored.

Purpose of the Study:

  • To investigate the correlation between serum SOD levels and vascular function/structure parameters.
  • To assess SOD's association with cardiovascular risk in patients with hypertension and type 2 diabetes.

Main Methods:

  • Enrolled 255 hypertensive and diabetic patients and 52 controls.
  • Measured serum SOD levels using an enzyme-linked immunosorbent assay kit.
  • Evaluated vascular parameters: pulse wave velocity, augmentation index, ambulatory arterial stiffness index, and carotid intima-media thickness.

Main Results:

  • Serum SOD showed negative correlations with pulse wave velocity, augmentation index, ambulatory arterial stiffness index, pulse pressure, and HDL-cholesterol.
  • Positive correlations were observed between SOD and plasma uric acid and triglycerides.
  • These findings suggest SOD levels reflect vascular alterations.

Conclusions:

  • Serum SOD levels are significantly correlated with vascular structure and function parameters in hypertensive and diabetic patients.
  • Changes in serum SOD levels serve as a marker for cardiovascular alterations in this patient population.

More Related Videos

Assessment of Vascular Function in Patients With Chronic Kidney Disease08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.9K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

2.2K

Related Concept Videos

Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
1.4K
Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
4.8K
Hypertension III: Clinical Manifestations and Diagnostic Studies01:30

Hypertension III: Clinical Manifestations and Diagnostic Studies

Hypertension is asymptomatic and also referred to as the "silent killer" until it progresses to a severe stage or causes target organ disease. Patients may experience symptoms stemming from the strain on blood vessels and tissues in various organs or the heart's increased workload.Physical exams might show no abnormalities other than high blood pressure. Signs of vascular damage, when present, correspond to the organs supplied by the affected vessels, leading to target organ damage. For...
714
Antihypertensive Drugs: Vasodilators01:23

Antihypertensive Drugs: Vasodilators

Vasodilators, primarily affecting the smooth muscles within arterial and venous walls, are commonly used for hypertension treatment. Medications such as minoxidil and hydralazine primarily target arteries and arterioles, while sodium nitroprusside acts on arterioles and venules. Minoxidil, functioning as a prodrug, is metabolized by hepatic sulfotransferase into its active form, minoxidil sulfate, after oral administration. This metabolite binds to the sulfonylurea receptor (SUR) component of...
2.5K
Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors01:30

Antihypertensive Drugs: Angiotensin-Converting Enzyme Inhibitors

Angiotensin-converting enzyme (ACE), a vital component of the renin-angiotensin-aldosterone system, is abundant in lung endothelial cells. ACE converts the inactive decapeptide, angiotensin I, into the active octapeptide, angiotensin II. This potent vasoconstrictor narrows blood vessels, increasing resistance to blood flow and elevating blood pressure. Angiotensin II also stimulates aldosterone production, encouraging kidney cells to reabsorb more sodium and water from urine, thereby increasing...
2.8K