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Staphylococcus aureus vs. Osteoblast: Relationship and Consequences in Osteomyelitis
Jérôme Josse1, Frédéric Velard1, Sophie C Gangloff1
1EA 4691 Biomatériaux et inflammation en site osseux, Pôle Santé, Université de Reims Champagne-Ardenne Reims, France.
Frontiers in Cellular and Infection Microbiology
|December 5, 2015
Summary
Staphylococcus aureus infection disrupts bone homeostasis by altering osteoblast function and viability. New antimicrobial therapies are needed to combat bacteria within bone cells.
Area of Science:
- Bone biology and microbiology
- Infectious diseases
- Immunology
Background:
- Osteoblasts and osteoclasts maintain bone homeostasis through formation and resorption.
- Staphylococcus aureus infection significantly impacts osteoblast activity and viability.
- The interaction between S. aureus and bone cells affects immune responses.
Purpose of the Study:
- To review the interaction between Staphylococcus aureus and osteoblasts.
- To explore the mechanisms by which S. aureus affects osteoblasts.
- To highlight the potential of antimicrobial peptides against intracellular S. aureus.
Main Methods:
- Literature review of studies on S. aureus and osteoblast interactions.
- Analysis of S. aureus-induced changes in osteoblast responses.
- Evaluation of antimicrobial peptide efficacy against intracellular S. aureus.
Main Results:
- S. aureus alters osteoblast production of chemokines, cytokines, and growth factors.
- Osteoblast apoptosis and reduced viability are induced by S. aureus.
- S. aureus infection modulates the osteoblast-osteoclast relationship.
- Antimicrobial peptides show potential in eliminating intracellular S. aureus.
Conclusions:
- Staphylococcus aureus significantly disrupts bone cell function and homeostasis.
- Osteoblasts play a role in immunity during S. aureus infections.
- Targeting intracellular S. aureus within osteoblasts is crucial for effective treatment.
- Development of novel anti-infectious therapeutics is necessary.
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