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Related Experiment Videos

Arsenic-induced skin toxicity.

R L Shannon1, D S Strayer

  • 1Department of Pathology and Laboratory Medicine, University of Texas Medical School, Houston 77030.

Human Toxicology
|March 1, 1989
PubMed
Summary
This summary is machine-generated.

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Inorganic arsenic exposure, from well water or medicine, can cause skin lesions and increase skin cancer risk. Some lesions may progress to invasive cancers, with a low mortality rate reported.

Area of Science:

  • Dermatology
  • Environmental Toxicology
  • Oncology

Background:

  • Inorganic arsenic exposure is a global health concern, linked to various environmental and occupational sources.
  • Arsenic contamination in drinking water and historical medicinal use are significant exposure pathways.
  • Cutaneous manifestations of arsenic exposure range from benign lesions to malignant skin cancers.

Purpose of the Study:

  • To review existing literature on the dermatological effects of inorganic arsenic.
  • To determine potential hazards associated with arsenic exposure.
  • To collate data on dosage, exposure, and skin cancer incidence.

Main Methods:

  • Systematic literature review of studies on inorganic arsenic and skin effects.
  • Analysis of data on arsenic exposure routes (occupational, medicinal, water).

Related Experiment Videos

  • Evaluation of reported skin lesions, including hyperpigmentation, hyperkeratosis, and various skin cancers.

    • Main Results:

    • Arsenic exposure is associated with benign skin lesions like hyperpigmentation and hyperkeratosis.
    • Hyperkeratotic lesions and squamous cell carcinoma in situ can progress to invasive squamous cell carcinoma.
    • Both de novo and progressive invasive squamous cell carcinomas, and basal cell carcinomas, have been linked to arsenic exposure.

    Conclusions:

    • Inorganic arsenic poses significant dermatological risks, including the development of skin cancers.
    • Dose-response relationships are observed with medicinal arsenic, but are less clear for drinking water exposure.
    • While mortality from arsenic-induced skin cancer is low, the potential for metastasis and local invasion necessitates awareness and preventative measures.