Related Experiment Video
Updated: Mar 29, 2026
07:36
Modeling Encephalopathy of Prematurity Using Prenatal Hypoxia-ischemia with Intra-amniotic Lipopolysaccharide in Rats
Published on: November 20, 2015
12.0K
Perinatal thrombosis: implications for mothers and neonates
1Division of Pediatric Hematology/Oncology, Nationwide Children's Hospital/Ohio State University, and Center for Innovation in Pediatric Practice, Research Institute at Nationwide Children's Hospital, Columbus, OH.
Hematology. American Society of Hematology. Education Program
|December 6, 2015
Summary
Perinatal stroke, including perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT), presents significant risks for long-term disabilities. Current treatments are limited, with a need for better prevention and therapeutic strategies.
Area of Science:
- Neurology
- Pediatrics
- Neonatology
Background:
- Perinatal stroke is a leading cause of childhood neurological and motor disabilities.
- It encompasses perinatal arterial ischemic stroke (PAIS) and cerebral sinovenous thrombosis (CSVT).
- Etiology is multifactorial, involving maternal, delivery, and neonatal factors.
Purpose of the Study:
- To review the epidemiology, natural history, risk factors, and treatment of PAIS and CSVT.
- To identify current knowledge gaps and areas for future research.
- To evaluate the role of thrombophilia screening and anticoagulation strategies.
Main Methods:
- Literature review of epidemiological data.
- Analysis of risk factors and etiological contributions.
- Evaluation of current and emerging treatment strategies.
Main Results:
- Perinatal stroke etiology is multifactorial; inherited thrombophilia requires further study but routine screening is not recommended.
- Treatment strategies for PAIS are limited; neuroprotection and alternative therapies are needed.
- Anticoagulation in CSVT appears safe and may prevent progression, but clinical trials are necessary to confirm efficacy.
Conclusions:
- Significant morbidity associated with perinatal stroke necessitates improved prevention and treatment.
- Further research into neuroprotection for PAIS and robust clinical trials for CSVT anticoagulation are crucial.
- Understanding the role of thrombophilia in long-term outcomes requires additional investigation.
Related Concept Videos
01:30Venous Thrombosis I: Introduction
681
Venous thrombosis, the most common disorder of the veins, involves the formation of a thrombus or blood clot associated with vein inflammation. It can be classified as either superficial vein thrombosis or deep vein thrombosis.Superficial Vein Thrombosis: This involves the formation of a thrombus in a superficial vein, usually the greater or lesser saphenous vein. Though less severe than deep vein thrombosis (DVT), SVT can lead to complications if untreated.Deep Vein Thrombosis (DVT): This...
681
01:29Venous Thrombosis III: Interprofessional Care
465
Venous thrombosis requires effective prevention and treatment strategies to improve patient outcomes and reduce potential complications.Prevention StrategiesHealthcare providers must prioritize preventing venous thromboembolism (VTE) for all adult patients upon admission. Interventions depend on bleeding and thrombosis risk, medical history, current medications, diagnoses, planned procedures, and patient preferences. Patients on bed rest should change positions every two hours and, if not...
465
01:30Venous Thrombosis IV: Nursing Management
379
Nursing management begins with a thorough assessment of the patient's health history. Key factors include trauma to veins, peripherally inserted central catheters, varicose veins, recent pregnancy or childbirth, surgery, bacteremia, prolonged bed rest, atrial fibrillation, COPD, heart failure, cancer, coagulation disorders, myocardial infarction, spinal cord injury, stroke, prolonged travel, recent bone fractures, and dehydration. Review medication intake, particularly oral contraceptives,...
379
01:14Fetal Circulation
4.5K
Fetal circulation is a unique system that facilitates the exchange of gases, nutrients, and waste products between the developing fetus and the mother. This intricate process takes place through a special organ called the placenta.
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
4.5K
01:27Pulmonary Embolism III: Nursing Management
657
A pulmonary embolism occurs when a thrombus, amniotic fluid, tumor tissue, fat, or air embolus blocks one or more pulmonary arteries. Effective nursing management and patient education are crucial for improving outcomes and preventing recurrence.Nursing management starts with obtaining a comprehensive patient history, particularly noting any history of deep vein thrombosis (DVT). Assess for clinical manifestations, including dyspnea, chest pain, crackles, heart murmurs, and signs of right-sided...
657
01:24Disorders of Hemostasis
2.7K
Hemostasis, the process that stops bleeding after a blood vessel injury, is crucial for maintaining the integrity of the circulatory system. However, disorders of hemostasis can disrupt this delicate balance, leading to either excessive clotting or bleeding. These disorders can be broadly classified into thromboembolic disorders and bleeding disorders.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
Thromboembolic Disorders
Two factors primarily cause thromboembolic conditions.
2.7K