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Long non-coding RNAs in colorectal cancer.
Xia Xie1, Bo Tang1, Yu-Feng Xiao1
1Department of Gastroenterology, Xinqiao Hospital, Third Military Medical University, Chongqing, P.R. China.
Oncotarget
|December 6, 2015
Summary
Long non-coding RNAs (lncRNAs) play a key role in colorectal cancer (CRC) development and progression. These molecules show potential as novel biomarkers for CRC diagnosis, prognosis, and therapy response prediction.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Colorectal cancer (CRC) remains a leading cause of cancer mortality globally, with limited improvement in survival rates despite advancements.
- CRC development is a complex, multi-step process where aberrant gene expression, particularly involving long non-coding RNAs (lncRNAs), is significant.
Purpose of the Study:
- To review the role of lncRNAs in colorectal cancer (CRC) development.
- To elucidate the regulatory mechanisms of lncRNAs in CRC.
- To explore the potential of lncRNAs as biomarkers for CRC diagnosis, prognosis, and therapy prediction.
Main Methods:
- Literature review focusing on studies investigating lncRNAs in CRC.
- Analysis of molecular mechanisms by which lncRNAs influence CRC development.
- Evaluation of lncRNAs as potential biomarkers in body fluids.
Main Results:
- lncRNAs regulate CRC through epigenetic modifications, lncRNA-miRNA interactions, and lncRNA-protein interactions.
- Some lncRNAs function as miRNA precursors or pseudogenes, impacting gene expression.
- Certain lncRNAs are detectable in body fluids, exhibiting specificity and accessibility.
Conclusions:
- lncRNAs are integral to colorectal cancer pathogenesis.
- lncRNAs offer promising avenues for novel diagnostic and prognostic biomarkers in CRC.
- Further research into lncRNAs could enhance CRC patient outcomes and treatment strategies.
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