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Loss of Residual Renal Function is Associated With Vascular Calcification in Hemodialysis Patients

Hung-Chih Chen1,2, Che-Yi Chou1,2, Jyun-Shan Jheng1,2

  • 1Kidney Institute and Division of Nephrology, Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan.

Therapeutic Apheresis and Dialysis : Official Peer-Reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy
|December 7, 2015
PubMed

Insights

Loss of residual renal function (RRF) in hemodialysis (HD) patients is linked to increased vascular calcification, measured by abdominal aortic calcification (AAC). This association remained significant even after accounting for other risk factors.

Area of Science:

  • Nephrology
  • Cardiovascular Medicine
  • Radiology

Background:

  • Vascular calcification (VC) is prevalent in chronic hemodialysis (HD) patients.
  • Abdominal aortic calcification (AAC) is a common measure of VC.
  • Loss of residual renal function (RRF) is a known predictor of mortality in HD patients.

Purpose of the Study:

  • To investigate the association between the loss of RRF and VC in HD patients.
  • To determine if RRF loss independently predicts vascular calcification.

Main Methods:

  • Cross-sectional study of 438 chronic HD patients from China Medical University Hospital (2014).
  • AAC scores were semi-quantitatively assessed using lumbar radiographs.
  • Loss of RRF was defined as urine output < 200 mL/day.
  • Logistic regression analysis was employed to assess the association.

Main Results:

  • Patients with loss of RRF had significantly higher AAC scores (median 9 vs 5, P=0.004).
  • Loss of RRF was independently associated with higher AAC scores.
  • This association persisted after adjusting for age, diabetes, C-reactive protein, calcium-phosphorus product, and dialysis vintage.

Conclusions:

  • Loss of residual renal function is significantly associated with increased vascular calcification in hemodialysis patients.
  • Preserving RRF may be crucial for mitigating cardiovascular risk in HD patients.

Keywords:
HemodialysisResidual Renal FunctionVascular Calcification

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