Coelomic epithelium-derived cells in visceral morphogenesis
Laura Ariza1,2, Rita Carmona1,2, Ana Cañete1,2
1University of Málaga, Faculty of Science, Department of Animal Biology, Málaga, Spain.
Summary
The embryonic coelomic epithelium provides mesenchymal cells crucial for organ development in vertebrates. This epithelial-mesenchymal transition is a vital, yet often overlooked, developmental process.
Area of Science:
- Developmental Biology
- Cell Biology
- Evolutionary Biology
Background:
- Vertebrate coelomic cavities are lined by mesothelium derived from lateral plate mesoderm.
- The coelomic epithelium actively generates mesenchymal cells and signaling molecules essential for organogenesis.
Purpose of the Study:
- To review the contribution of coelomic epithelium-derived cells to visceral development.
- To elucidate their developmental fates and signaling roles.
- To highlight the significance of epithelial-mesenchymal transition in this context.
Main Methods:
- Review of existing literature.
- Analysis of genetic lineage tracing studies.
- Synthesis of data on cell contributions and signaling functions.
Main Results:
- Coelomic epithelium-derived cells populate and contribute to the connective and vascular tissues of organs like the body wall, heart, liver, lungs, gonads, and gastrointestinal tract.
- These cells can differentiate into specialized types, including liver stellate cells, gut Cajal cells, and testicular Sertoli cells.
- Evidence highlights the widespread role of epithelial-mesenchymal transition from the coelomic epithelium in organ development.
Conclusions:
- The epithelial-mesenchymal transition of the embryonic coelomic epithelium is a fundamental and underestimated process in vertebrate organogenesis.
- This mechanism is likely conserved across coelomate metazoans, underscoring its evolutionary importance.
Keywords:
Wilms' tumor suppressor genecoelomic epitheliumepicardiumepithelial-mesenchymal transitionsmesotheliumMore Related Videos
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