Function and regulation of lymphocyte-mediated immune responses: relevance to bovine mastitis

Bovine mastitis is one of the most costly diseases to the dairy industry. Prospects for effective vaccines are limited by the variety of microorganisms capable of causing mastitis. An understanding of the physiologic and immunologic factors controlling the susceptibility of the cow to disease will lead to more rational approaches to prevention and control. In this paper, we describe the basic components of the immune system, drawing upon information derived from studies with rodents and humans. Some of these findings have been confirmed in the bovine and other domestic species, and it is likely that further study will reveal additional similarities between the immune systems of laboratory animals, humans, and domestic animals. Some important differences have already been identified, such as altered lymphocyte circulation patterns in ruminant versus non-ruminant species. These differences are discussed. We describe the structural and functional properties of major histocompatibility complex antigens and their role in regulation of immune responses. Finally, we discuss the consequences of antigen-induced activation of T-lymphocytes and the role of these cells in response to disease-causing microorganisms.