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Polysaccharide-based nanoparticles for theranostic nanomedicine
M Swierczewska1, H S Han2, K Kim3
1Russell H. Morgan Department of Radiology and Radiological Science, Center for Cancer Nanotechnology Excellence, Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University, 400 North Broadway, Baltimore, MD 21231, United States.
Advanced Drug Delivery Reviews
|December 8, 2015
Summary
Polysaccharide nanoparticles offer a versatile platform for theranostics, combining drug delivery and imaging. This review explores their formation methods and clinical potential, focusing on chitosan and hyaluronic acid nanoparticles.
Area of Science:
- Biomaterials Science
- Nanomedicine
- Theranostics
Background:
- Polysaccharides are natural molecules with inherent advantages for theranostics.
- They possess reactive groups for conjugating therapeutics and diagnostic agents.
- Their properties include biodegradability, abundance, low toxicity, and diverse size/charge.
Purpose of the Study:
- To review polysaccharide-based nanoparticles for theranostic applications.
- To focus on nanoparticle formation methods (self-assembled, cross-linked).
- To highlight clinical potential, especially for chitosan and hyaluronic acid NPs.
Main Methods:
- Review of existing literature on polysaccharide-based theranostic systems.
- Analysis of nanoparticle formation strategies.
- Case studies of chitosan and hyaluronic acid nanoparticle applications.
Main Results:
- Polysaccharide nanoparticles serve as effective platforms for simultaneous drug delivery and imaging.
- Various methods exist for engineering these nanoparticles, including self-assembly and cross-linking.
- Chitosan and hyaluronic acid are prominent polysaccharides for developing theranostic nanomedicines.
Conclusions:
- Polysaccharide-based nanoparticles are promising for clinical theranostics.
- Engineering nanoparticle formation is key to their theranostic efficacy.
- Chitosan and hyaluronic acid NPs show significant potential for integrated diagnostics and therapeutics.
