Regadenoson stress for myocardial perfusion imaging
Eliana Reyes1,2
1Nuclear Medicine Department, Royal Brompton Hospital, London, SW3 6NP, UK.
Insights
Regadenoson stress testing is a valuable tool for diagnosing coronary artery disease (CAD) by assessing myocardial perfusion. This review covers regadenoson
Area of Science:
- Cardiology
- Nuclear Cardiology
- Pharmacology
Background:
- Noninvasive functional imaging is crucial for diagnosing hemodynamically significant coronary artery disease (CAD).
- Cardiac stress agents are essential for detecting abnormal myocardial perfusion indicative of coronary stenosis.
- Regadenoson is a widely used pharmacological vasodilator for cardiac stress testing.
Purpose of the Study:
- To provide an updated review of regadenoson stress testing for CAD assessment.
- To familiarize clinicians with regadenoson's properties, protocols, efficacy, and safety.
Main Methods:
- Review of pharmacological properties of regadenoson.
- Description of regadenoson stress protocols.
- Analysis of efficacy and safety data for regadenoson in CAD patients.
Main Results:
- Regadenoson is an effective and safe pharmacological stress agent.
- It is increasingly utilized as a primary or alternative stress modality.
- The review details its pharmacological actions and clinical application.
Conclusions:
- Regadenoson stress testing is a valuable tool for evaluating patients with suspected or known CAD.
- Understanding its use is important for clinicians managing CAD.
- The article offers comprehensive insights into regadenoson's role in myocardial perfusion imaging.
Abstract:
Noninvasive functional imaging plays a major role in the diagnosis of hemodynamically significant coronary artery disease (CAD) by means of the detection of abnormal myocardial perfusion. For this, cardiac stressors are essential as they induce hypoperfusion in the presence of flow-limiting coronary stenosis. Several pharmacological stressors are currently available and it is important that clinicians who are involved in the care and management of patients with CAD become familiar with their indications, contraindications and protocols. Among the primary coronary vasodilator agents, regadenoson is increasingly used as the default stressor or as an alternative to other modalities of stress. This article provides an updated review of regadenoson stress for the assessment of patients with suspected or known CAD and describes its pharmacological properties, stress protocol, efficacy and safety profile.
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