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Zinc Deficiency Increases Serum Concentrations of Parathyroid Hormone through a Decrease in Serum Calcium and Induces
Takako Suzuki1, Yasutaka Kajita, Shin-ichi Katsumata
1Department of Nutritional Science, Faculty of Applied Bioscience, Tokyo University of Agriculture.
Journal of Nutritional Science and Vitaminology
|December 8, 2015
Summary
Zinc deficiency in rats led to reduced bone density and impaired bone metabolism. This was linked to altered calcium regulation and increased parathyroid hormone, causing bone fragility.
Area of Science:
- Nutritional Science
- Bone Biology
- Endocrinology
Background:
- Zinc is essential for bone health and metabolic processes.
- Dietary zinc levels can impact skeletal integrity and hormonal balance.
Purpose of the Study:
- To investigate the effects of zinc deficiency on bone mineral composition, bone remodeling markers, and hormones.
- To determine the impact of zinc deficiency on bone metabolism and calcium homeostasis.
Main Methods:
- Wistar rats were fed zinc-adequate, zinc-deficient, or pair-fed diets for 4 weeks.
- Evaluated bone mineral density, mechanical properties, serum and urine markers of bone turnover, and mineral and hormone concentrations.
Main Results:
- Zinc deficiency reduced bone mineral density and mechanical strength.
- Bone formation markers decreased, while bone resorption markers increased in zinc-deficient rats.
- Zinc deficiency impaired calcium homeostasis, leading to increased parathyroid hormone levels.
Conclusions:
- Zinc deficiency negatively affects bone metabolism and increases bone fragility.
- Altered calcium homeostasis and elevated parathyroid hormone contribute to the skeletal effects of zinc deficiency.
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