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Related Concept Videos

Regression Toward the Mean01:52

Regression Toward the Mean

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Regression toward the mean (“RTM”) is a phenomenon in which extremely high or low values—for example, and individual’s blood pressure at a particular moment—appear closer to a group’s average upon remeasuring. Although this statistical peculiarity is the result of random error and chance, it has been problematic across various medical, scientific, financial and psychological applications. In particular, RTM, if not taken into account, can interfere when...
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Development of the Oral Microbiota01:28

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The establishment of the oral microbiome begins before birth, challenging the long-held belief that the fetal oral cavity is sterile. The presence of oral microbes such as Streptococcus and Fusobacterium in amniotic fluid suggests that microbial exposure may occur in utero, potentially through translocation from the maternal oral or gastrointestinal tract. This early colonization primes the neonatal immune system and sets the stage for subsequent microbial succession. Maternal health,...
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Articles linked to this work by shared authors, journal, and citation graph.

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Same author

Biomarker screen-guided care for preterm birth risk in nulliparous pregnancies: a subgroup analysis of the PRIME randomized controlled trial.

The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·2026
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The association of maternal body mass index and cesarean delivery after preterm induction of labor.

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Disparities in low dose aspirin use for preeclampsia risk reduction and opportunities for improvement.

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Related Experiment Video

Updated: Mar 29, 2026

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting
14:43

A Novel Method for Involving Women of Color at High Risk for Preterm Birth in Research Priority Setting

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Future directions in preterm birth research.

Joses Jain1, Cynthia Gyamfi-Bannerman1

  • 1Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Seminars in Fetal & Neonatal Medicine
|December 8, 2015
PubMed
Summary

Innovative research into preterm birth is crucial, as current interventions are ineffective for most cases. Future studies will explore cervical evaluation, the microbiome, and molecular/epigenetic factors to find new solutions.

Keywords:
CervixGenomicsMicrobiomePreterm birthResearch

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Area of Science:

  • Obstetrics and Gynecology
  • Reproductive Biology
  • Genetics

Background:

  • Preterm birth is a complex global health challenge with limited effective interventions.
  • Current treatments fail in approximately 95% of spontaneous preterm birth cases, necessitating novel approaches.

Purpose of the Study:

  • To outline promising future research directions for understanding and preventing preterm birth.
  • To highlight innovative strategies beyond current therapeutic limitations.

Main Methods:

  • Review of emerging research areas in preterm birth.
  • Focus on advanced cervical evaluation techniques.
  • Exploration of microbiome and molecular/epigenetic research strategies.

Main Results:

  • Identification of key areas for future preterm birth research.
  • Emphasis on interdisciplinary approaches combining various scientific fields.
  • Highlighting the potential of novel diagnostic and therapeutic targets.

Conclusions:

  • Advanced cervical assessment, microbiome analysis, and molecular/epigenetic research offer promising avenues.
  • Innovative research is essential to overcome the limitations of current preterm birth interventions.
  • Future discoveries in these areas could significantly impact preterm birth rates and outcomes.