Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Structural plasticity at identified synapses during long-term memory in Aplysia.

C H Bailey1, M Chen

  • 1Department of Anatomy, College of Physicians and Surgeons, Columbia University, New York, New York.

Journal of Neurobiology
|July 1, 1989
PubMed
Summary

Long-term memory in Aplysia involves structural changes at sensory neuron synapses. Learning and memory formation may rely on neuronal growth and synaptic plasticity across diverse animal species.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A population-based study of the incidence of delusional infestation in Olmsted County, Minnesota, 1976-2010.

The British journal of dermatology·2014
Same author

EFFECTS ON TITRATIONS OF INEQUALITY OF SENSITIZATION OF CORPUSCLES.

The Journal of experimental medicine·2009
Same author

ATHEROMA AND OTHER LESIONS PRODUCED IN RABBITS BY CHOLESTEROL FEEDING.

The Journal of experimental medicine·2009
Same author

THE PRODUCTION OF AMYLOID DISEASE AND CHRONIC NEPHRITIS IN RABBITS BY REPEATED INTRAVENOUS INJECTIONS OF LIVING COLON BACILLI.

The Journal of experimental medicine·2009
Same author

THE PRODUCTION OF ARTERIOSCLEROSIS AND GLOMERULONEPHRITIS IN THE RABBIT BY INTRAVENOUS INJECTIONS OF DIPHTHERIA TOXIN.

The Journal of experimental medicine·2009
Same author

Is heterosynaptic modulation essential for stabilizing Hebbian plasticity and memory?

Nature reviews. Neuroscience·2001

Area of Science:

  • Neuroscience
  • Cell Biology
  • Behavioral Science

Background:

  • Synaptic plasticity underlies learning and memory.
  • Long-term habituation and sensitization in Aplysia involve changes in synaptic effectiveness.
  • Identified sensory neuron synapses are critical sites for short-term learning plasticity.

Purpose of the Study:

  • To determine the morphological basis of prolonged changes in synaptic effectiveness.
  • To investigate structural alterations in sensory neuron synapses during long-term habituation and sensitization.
  • To explore the role of synaptic plasticity in long-term memory.

Main Methods:

  • Utilized the gill- and siphon-withdrawal reflex in Aplysia californica.
  • Examined structural changes at identified sensory neuron synapses.

Related Experiment Videos

  • Quantitatively analyzed active zones and presynaptic varicosities.

    • Main Results:

    • Structural changes in sensory neuron synapses correlate with behavioral modification.
    • Sensitized Aplysia showed larger active zones and more varicosities; habituated Aplysia showed smaller ones.
    • Changes in synapse number persisted with memory retention.

    Conclusions:

    • Learning involves structural synaptic plasticity, including neuronal growth.
    • These findings suggest a conserved mechanism of synaptic plasticity across the animal kingdom.
    • Structural alterations at sensory neuron synapses are key to long-term memory in Aplysia.