Related Experiment Video
Updated: Mar 29, 2026

Ex Situ Normothermic Machine Perfusion of Donor Livers
Published on: May 26, 2015
Pathologic Criteria to Estimate the State of the Liver in Potential Donors
Caliya Shaimardanova1, Galina Fedotovskikh, Aleksandr Savchuk
1From the Department of Pathology, JSC National Scientific Medical Research Center, Astana, Kazakhstan.
Objectives:
The pathologic evaluation of the liver is one of the most important issues in liver transplants. We evaluated the histopathological condition of livers in potential donors.
Materials And Methods:
After liver biopsy, 37 potential donor livers were histologically studied. Liver tissue was stained by hematoxylin and eosin as well as Masson Trichrome.
Results:
The results of the study showed the morphologic criteria used to estimate the state of the liver in potential donors is not only steatosis and fibrosis, but other important histologic criteria, such as proteinosis, necrosis of hepatocytes, endotheliitis of central veins, inflammatory infiltration, endarteritis in portal tracts and phlebitis in portal tracts, proliferation of the bile ducts, and cholestasis.
Conclusions:
Results of the study showed that the morphologic criteria to estimate the state of the liver in potential donors includes not only steatosis and fibrosis, but other important histologic criteria as well.
Related Concept Videos
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test
Kidney Transplant I: Introduction
Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

