Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Pharmacokinetics in Pediatric Patients: Drug Metabolism

Pharmacokinetics in Pediatric Patients: Drug Metabolism

In pediatric care, understanding the nuances of hepatic drug metabolism is crucial, as it significantly differs from that of adults. This divergence is primarily due to the developmental stage of drug-metabolizing enzymes, which affects how medications are processed in the body. In neonates, for instance, the activity of Phase I enzymes—critical for the initial breakdown of drugs—is markedly reduced, functioning at just 20–40% of the levels seen in adults. This reduction poses...

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Pharmacokinetics in Pediatric Patients: Overview and Drug Absorption

Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

Diseases of the Liver and Gallbladder

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...

Pharmacokinetics in Pediatric Patients: Drug Excretion

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Effect of Hepatic Disease on Pharmacokinetics: Drug Dosing and Hepatic Blood Flow

Chronic liver disease significantly impacts drug metabolism due to alterations in hepatic blood flow and enzyme accessibility. This disruption affects the body's pharmacokinetics—the movement and processing of drugs within the system. Key enzymes crucial for metabolizing medications become less accessible, changing how drugs are processed and utilized. Furthermore, liver disease influences the synthesis of plasma proteins, such as albumin and globulins, which play critical roles in drug...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Omalizumab for severe IgE-mediated food allergy and severe asthma after pediatric liver transplantation: a case report.

Frontiers in pediatrics·2026

Same author

European Society for Pediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) position paper on screening, diagnosis and investigation of paediatric metabolic dysfunction-associated steatotic liver disease.

Journal of pediatric gastroenterology and nutrition·2026

Same author

Thrombin Generation in Acute and Chronic Liver Disease in Children.

Diagnostics (Basel, Switzerland)·2026

Same author

Pre-, Pro-, Post- and Synbiotics in Pediatric Short Bowel Syndrome: A Narrative Review of Current Evidence.

Children (Basel, Switzerland)·2026

Same author

Artificial Intelligence in hepatology: A position paper by the Italian Association for the Study of the Liver.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2026

Same author

The <i>KLB</i> rs12152703 variant confers protection against hepatic inflammation in patients with MASLD by boosting Klotho-beta expression.

JHEP reports : innovation in hepatology·2026

Search research articles

Related Experiment Video

Updated: Mar 29, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Pediatric liver diseases: current challenges and future perspectives.

Claudia Della Corte¹, Antonella Mosca², Andrea Vania²

¹a Hepato-Metabolic Department , Bambino Gesù Children's Hospital, IRCCS , Rome , Italy.

Expert Review of Gastroenterology & Hepatology

|December 8, 2015

Summary

Pediatric chronic liver diseases are a growing concern, often diagnosed late due to subtle symptoms. Recent advances improve understanding, diagnosis, and treatment of these childhood liver conditions.

Keywords:

Children Wilson disease autoimmune hepatitis chronic viral hepatitis liver disease nonalcoholic fatty liver disease treatment

More Related Videos

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Published on: January 19, 2024

Related Experiment Videos

Last Updated: Mar 29, 2026

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma

Published on: September 30, 2021

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

Published on: January 19, 2024

Area of Science:

Pediatric Hepatology
Gastroenterology
Public Health

Background:

Chronic liver diseases in children are increasing and can lead to adult liver conditions like cirrhosis and cancer.
These conditions are often under-recognized and diagnosed late in pediatric populations.
Lack of early symptoms complicates timely diagnosis and intervention.

Purpose of the Study:

To review recent advances in understanding the pathogenesis of pediatric liver diseases.
To discuss the latest diagnostic approaches for common childhood liver conditions.
To highlight novel therapeutic targets and treatments for pediatric liver diseases.

Main Methods:

Review of recent scientific literature on pediatric liver diseases.
Analysis of current diagnostic strategies and their limitations.
Evaluation of emerging therapeutic targets and treatment modalities.

Main Results:

Significant progress has been made in understanding the underlying mechanisms of pediatric liver diseases.
New diagnostic tools are improving early detection rates.
Therapeutic advancements offer improved outcomes for affected children.

Conclusions:

Early recognition and diagnosis are crucial for managing pediatric liver diseases.
Continued research into pathogenesis and treatment is vital for improving long-term outcomes.
Advances in understanding and treatment are transforming the natural history of childhood liver conditions.