Variance of Serum Lipid Levels in Stroke Subtypes
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Published on: November 10, 2017
Insights
Dyslipidemia, including high LDL-C and TC, is linked to atherosclerotic stroke. Specific lipid profiles differentiate stroke subtypes, with LDL-C and TC predicting large-artery atherosclerotic stroke.
Area of Science:
- Neuroscience
- Cardiovascular Medicine
- Biochemistry
Background:
- Epidemiological studies link dyslipidemia to atherosclerotic stroke.
- Lipid metabolism varies across ischemic stroke subtypes.
- Limited research exists on dyslipidemia's role in specific ischemic stroke subtypes.
Purpose of the Study:
- To investigate the relationship between acute ischemic stroke subtypes and serum lipid levels.
- To identify specific lipid profile differences among stroke subtypes.
Main Methods:
- Serum lipid levels (TC, TG, LDL-C, HDL-C, apoA, apoB, apoE, LP(a)) were measured in 362 ischemic stroke patients and 181 controls.
- Lipid levels were analyzed according to TOAST classification for stroke subtypes.
Main Results:
- Patients exhibited higher TC, TG, LDL-C, apoA, apoB, apoE, LP(a) and lower HDL-C than controls.
- Elevated TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C ratios were observed in patients.
- Large-artery atherosclerosis subtype showed higher TC, TG, LDL-C, apoA, apoB, apoE, LP(a) and lower HDL-C compared to cardioembolism.
- Cardioembolism subtype had higher LP(a), TC, and TC/HDL-C than small-vessel occlusion.
- Significant differences in lipid profiles were found between large-artery atherosclerosis and small-vessel occlusion subtypes.
Conclusions:
- Low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) may serve as independent predictors for large-artery atherosclerotic stroke.
- Serum lipid profiles are significantly associated with specific ischemic stroke subtypes.
Background:
An increasing number of epidemiological studies have identified a close relationship between dyslipidemia and atherosclerotic stroke. Indeed, lipid metabolism is significantly different among the different ischemic stroke subtypes. There are few studies available regarding risk factors for specific subtypes of ischemic stroke, and in particular, there is little evidence about the role of dyslipidemia. The aim of this study is to determine the relationship between acute ischemic stroke subtype and serum lipid level.
Methods:
The levels of serum lipid including TC, TG, LDL-C, HDL-C, apoA, apoB, apoE, and LP (a) were tested in 362 ischemic stroke patients and 181 healthy controls. Lipid levels were analyzed in stroke subtypes according to the TOAST classification.
Results:
Levels of TC, TG, LDL-C, apoA, apoB, apoE, and LP (a) were significantly higher and HDL-C levels were significantly lower in the patient group relative to control. The TC/HDL-C ratio, TG/HDL-C ratio, and LDL-C/HDL-C ratio were remarkably higher in the patient group. The levels of TC, TG, LDL-C, apoA, apoB, apoE, and LP(a) were markedly higher and HDL-C was markedly lower in the large-artery atherosclerosis stroke subtype relative to the cardioembolism subtype. Compared with the small-vessel occlusion group, the level of LP(a), TC, and TC/HDL-C were strikingly higher in the cardioembolism group. The TC/HDL-C ratio was different among subgroups, with the large-artery atherosclerosis group exhibiting the highest value. For TC, TG, LDL-C, apoA, apoB, apoE, LP(a), TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C levels a statistically significant difference was found between the large-artery atherosclerosis group and the small-vessel occlusion group.
Conclusions:
We found that LDL-C and TC levels may be independent predictors for the occurrence of large-artery atherosclerotic stroke.
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