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Prefrontal-hippocampal pathways underlying inhibitory control over memory.

Michael C Anderson1, Jamie G Bunce2, Helen Barbas2

  • 1MRC Cognition & Brain Sciences Unit, 15 Chaucer Road, Cambridge, England CB2 7EF, United Kingdom.

Neurobiology of Learning and Memory
|December 9, 2015
PubMed
Summary
This summary is machine-generated.

This study explores how the brain stops unwanted memories, proposing two pathways for inhibitory control. Understanding these pathways could help treat disorders with intrusive thoughts.

Keywords:
Anterior cingulateForgettingHippocampusInhibitory controlNucleus reuniensRetrieval suppression

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Area of Science:

  • Neuroscience
  • Cognitive Psychology
  • Neuroanatomy

Background:

  • The prefrontal cortex (PFC) is crucial for inhibitory control over behavior.
  • This inhibitory function is believed to extend to cognitive processes, including memory retrieval.
  • The right lateral PFC plays a role in retrieval suppression, the ability to intentionally stop memory recall.

Purpose of the Study:

  • To elucidate the anatomical pathways mediating inhibitory control during retrieval suppression.
  • To integrate functional imaging findings with anatomical data from non-human primates.
  • To propose specific hypotheses regarding the neural mechanisms of retrieval suppression.

Main Methods:

  • Integration of functional imaging data on retrieval suppression.
  • Detailed analysis of relevant anatomical pathways in non-human primates.
  • Formulation of hypotheses on PFC-medial temporal lobe interactions.

Main Results:

  • Two hypotheses proposed: entorhinal gating and thalamo-hippocampal modulation via nucleus reuniens.
  • Entorhinal gating hypothesized for proactive retrieval stopping.
  • Thalamo-hippocampal modulation hypothesized for reactive interruption of ongoing retrieval.

Conclusions:

  • Identifying the anatomical pathways of retrieval suppression is key to understanding cognitive inhibitory control.
  • These findings may advance treatments for psychiatric disorders involving intrusive thoughts.
  • This research provides a model system for studying inhibitory control over cognition.