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Tuning Endothelial Permeability with Functionalized Nanodiamonds.

Magdiel I Setyawati1, Vadym N Mochalin2, David T Leong1

  • 1Department of Chemical and Biomolecular Engineering, National University of Singapore , 4 Engineering Drive 4, Singapore 117585, Singapore.

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|December 9, 2015
PubMed
Summary
This summary is machine-generated.

Nanodiamonds enhance cancer drug delivery by making tumor blood vessels leaky. This allows more doxorubicin to reach cancer cells, improving treatment effectiveness and tumor cell killing.

Keywords:
cancer drug deliveryendothelial cellsnanodiamondnanomedicinevascular barrier leakiness

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Research

Background:

  • Effective cancer nanomedicine delivery requires crossing the tumor vascular barrier.
  • Nanoparticles must navigate physiological barriers to reach tumor sites for therapeutic efficacy.

Purpose of the Study:

  • To investigate how nanodiamond (ND) variants influence vascular barrier permeability.
  • To explore the mechanisms underlying ND-induced vascular leakiness.
  • To assess the impact of enhanced vascular permeability on drug delivery and cancer cell killing.

Main Methods:

  • Utilized various nanodiamond (ND) variants with different surface functionalizations.
  • Measured intracellular reactive oxygen species (ROS) and calcium (Ca2+) levels in endothelial cells.
  • Assessed endothelial cell-cell connections and cytoskeletal remodeling.
  • Quantified doxorubicin penetration across the vascular barrier and its anti-cancer effects.

Main Results:

  • Nanodiamonds induced surface-dependent vascular barrier leakiness.
  • ND-mediated leakiness was driven by increased intracellular ROS and Ca2+.
  • This process disrupted endothelial cell-cell junctions and altered cytoskeletal structure.
  • Increased vascular permeability facilitated greater doxorubicin penetration, enhancing cancer cell killing.

Conclusions:

  • Tuning nanodiamond surface properties can modulate vascular barrier permeability.
  • This strategy offers a novel approach for enhancing nanomedicine traversal across vascular barriers in cancer therapy.
  • Surface-functionalized nanodiamonds show potential for improving drug delivery and therapeutic outcomes in cancer treatment.