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Updated: Aug 14, 2026

Sodium Taurocholate Induced Severe Acute Pancreatitis in C57BL/6 Mice
Published on: June 28, 2021
Incretin-based therapies are associated with acute pancreatitis: Meta-analysis of large randomized controlled trials
Pavel S Roshanov1, Brittany B Dennis2
1Schulich School of Medicine and Dentistry, Western University, 1465 Richmond St, London, ON N6G 2M1, Canada.
Abstract:
Previous studies have offered weak and conflicting evidence regarding the impact of incretin-based oral antihyperglycemic agents on risk of acute pancreatitis. This meta-analysis of three recent mega-trials found an 82% increase in the odds of acute pancreatitis with the use of these agents compared to usual care (95% CI, 1.17-2.82).
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