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Isolation of Human Myoblasts, Assessment of Myogenic Differentiation, and Store-operated Calcium Entry Measurement
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The store-operated Ca(2+) entry-mediated signaling is important for cancer spread

Yih-Fung Chen1, Keng-Fu Hsu2, Meng-Ru Shen3

  • 1Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung, Taiwan; Center for Research Resources and Development, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Pharmacology, National Cheng Kung University, Tainan, Taiwan.

Biochimica Et Biophysica Acta
|December 9, 2015
PubMed

Insights

Stromal interaction molecules (STIM) and Orai proteins regulate calcium signaling, impacting cancer cell migration and metastasis. Targeting these store-operated calcium entry (SOCE) pathways offers potential for novel cancer therapeutics.

Area of Science:

  • Cellular Biology
  • Cancer Research
  • Molecular Medicine

Background:

  • Tumor cell migration and invasion are critical steps in metastasis, significantly affecting patient prognosis.
  • Calcium (Ca2+) signaling dynamics are crucial for regulating cell migration processes, including cytoskeletal changes and focal adhesion.
  • Stromal interaction molecules (STIM) and Orai proteins are key components of store-operated calcium entry (SOCE), a vital calcium influx pathway.

Purpose of the Study:

  • To review recent advancements in understanding the role of STIM/Orai-mediated SOCE in cancer cell migration and metastasis.
  • To discuss the regulatory mechanisms governing STIM/Orai function in cancer spread.
  • To explore the clinical significance, diagnostic/prognostic potential, and therapeutic implications of targeting STIM/Orai in cancer.

Main Methods:

  • Literature review of recent research on STIM/Orai proteins and calcium signaling in cancer.
  • Analysis of studies investigating the link between SOCE and tumor progression.
  • Examination of clinical data and therapeutic strategies related to STIM/Orai pathways.

Main Results:

  • STIM and Orai proteins play significant roles in regulating cancer cell migration and invasion.
  • STIM/Orai-mediated SOCE is implicated in various aspects of the metastatic cascade.
  • The clinical significance of STIM/Orai in tumor progression and their potential as biomarkers have been demonstrated.

Conclusions:

  • STIM/Orai-mediated SOCE is a critical regulator of cancer cell metastasis.
  • Understanding these pathways provides insights into tumor progression.
  • Targeting STIM/Orai represents a promising therapeutic strategy for cancer treatment.
Keywords:
InvasionMetastasisMigrationOraiStore-operated Ca(2+) entry (SOCE)Stromal interaction molecule (STIM)

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