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Cognitive and psychiatric abnormalities in multiple sclerosis.

R C Petersen1, E Kokmen

  • 1Department of Neurology, Mayo Clinic, Rochester, MD 55905.

Mayo Clinic Proceedings
|June 1, 1989
PubMed
Summary
This summary is machine-generated.

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Multiple sclerosis (MS) increasingly affects behavior, including cognitive and psychiatric changes. Research now recognizes cerebral dysfunction

Area of Science:

  • Neurology
  • Neuroscience
  • Psychiatry

Background:

  • Multiple sclerosis (MS) was traditionally viewed as a spinal cord and brain stem disorder.
  • Recent findings highlight the significant role of cerebral dysfunction in MS.
  • Behavioral changes, encompassing cognitive and psychiatric abnormalities, are increasingly prevalent in MS patients.

Purpose of the Study:

  • To investigate the expanding understanding of behavioral changes in multiple sclerosis.
  • To explore the link between cerebral dysfunction and cognitive/psychiatric alterations in MS.
  • To evaluate the extent of impairment in various cognitive functions and the nature of psychiatric disorders in MS.

Main Methods:

  • Review of current literature on multiple sclerosis and its neurological and psychiatric manifestations.

Related Experiment Videos

  • Analysis of observed cognitive impairments, focusing on memory, conceptual processes, attention, and visuospatial skills.
  • Evaluation of psychiatric diagnoses, particularly affective disorders, in the context of MS.

    • Main Results:

    • Cerebral dysfunction is increasingly recognized as a key factor in multiple sclerosis.
    • Memory and conceptual processing appear to be preferentially affected cognitive functions.
    • Affective disorders are the most common psychiatric diagnoses in individuals with MS.

    Conclusions:

    • Behavioral changes are a significant and recognized component of multiple sclerosis.
    • The role of cerebral dysfunction in MS-related cognitive and psychiatric issues is a critical area of ongoing research.
    • Further investigation is needed to determine if observed psychiatric abnormalities stem from the demyelination process or are reactive to MS-related disability.