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Genome-wide Association Studies-GWAS01:11

Genome-wide Association Studies-GWAS

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
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Related Experiment Video

Updated: Mar 29, 2026

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis and uric acid: a population-based cross-sectional study.

Y C Lai1, Y W Yew2

  • 1Harvard TH Chan School of Public Health, Boston, MA, USA.

Clinical and Experimental Dermatology
|December 9, 2015
PubMed
Summary

Psoriasis is not an independent risk factor for high uric acid or gout. Metabolic syndrome, linked to psoriasis, may explain elevated serum uric acid levels.

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Area of Science:

  • Dermatology
  • Rheumatology
  • Metabolic Diseases

Background:

  • Psoriasis is linked to elevated serum uric acid and gout.
  • Uric acid plays a role in inflammatory pathways.

Purpose of the Study:

  • To investigate the association between psoriasis, serum uric acid levels, and gout.
  • Utilized data from the US National Health and Nutrition Examination Survey (NHANES).

Main Methods:

  • Cross-sectional study analyzing questionnaire and laboratory data (2003-2006, 2011-2012).
  • Multivariate logistic regression used to assess hyperuricemia risk factors.
  • Independent variables included demographics, metabolic syndrome, lifestyle factors, and psoriasis history.

Main Results:

  • Psoriasis patients showed higher risk for hyperuricemia (OR=1.37) and gout (OR=1.83) in unadjusted analysis.
  • These associations were not significant after adjusting for confounders.
  • 13.2% of participants had hyperuricemia; 2.6% reported psoriasis history.

Conclusions:

  • Insufficient evidence suggests psoriasis is an independent risk factor for hyperuricemia or gout.
  • Elevated serum uric acid may be linked to metabolic syndrome, which is associated with psoriasis.